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Cat. No.: HY-187552

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F050

F050 is an orally active intracellular platelet calcium ([Ca²⁺]i) inhibitor. F050 inhibits thrombin-induced elevation of intracellular calcium in platelets. F050 inhibits platelet aggregation induced by CaCl₂, arachidonic acid, collagen, adenosine diphosphate (ADP), and thrombin across multiple species, and reduces thrombus formation in an extracorporeal circulation thrombosis model in guinea pigs. F050 also inhibits hypotonic NaCl-induced erythrocyte hemolysis and is used in research on thrombotic diseases.

For research use only. We do not sell to patients.

CAS No.: 186835-06-3
Formula: C₂₁H₂₀O
Molecular Weight:288.38

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Please store the product under the recommended conditions in the Certificate of Analysis.

F050 Chemical Structure

CAS No.: 186835-06-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

F050 inhibits CaCl₂-, arachidonic acid-, collagen-, ADP-, and thrombin-induced platelet aggregation in guinea pig, rabbit, and rat platelets in vitro, with a wider spectrum of actions than Acetylsalicylic acid (HY-14654)^[1].
F050 inhibits hypotonic NaCl-induced hemolysis of guinea pig erythrocytes in vitro^[1].
F050 inhibits thrombin-induced increases in [Ca²⁺]ᵢ in guinea pig platelets in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 186835-06-3
Molecular Weight 288.38
Formula C₂₁H₂₀O
SMILES

OCCCC1=CC(C2=CC=CC=C2)=C(C3=CC=CC=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hongou K, et al. Antithrombotic effects of 3-([1:1',2':1"]-3'-terphenyl)propanol in animals. Arzneimittel-Forschung. 1997 Oct;47(10):1104-8.

[2]. Chen C, et al. Structure, rheological, thermal conductive and electrical insulating properties of high-performance hybrid epoxy/nanosilica/AgNWs nanocomposites[J]. Composites Science and Technology, 2016, 128: 207-214.

[3]. Hamel E, et al. Cornigerine, a potent antimitotic Colchicum alkaloid of unusual structure: interactions with tubulin[J]. Biochemical pharmacology, 1988, 37(12): 2445-2449.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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