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Cat. No.: HY-15187B

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Filanesib TFA

Name: Filanesib TFA
Brand: MedChemExpress
SKU: HY-15187B
Availability: PreOrder

(Synonyms: ARRY-520 TFA)

7 Cited Publications

Customer Review

Based on 7 publication(s) in Google Scholar

Filanesib TFA (ARRY-520 TFA) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity.

For research use only. We do not sell to patients.

CAS No.: 1781834-99-8
Formula: C₂₂H₂₃F₅N₄O₄S
Molecular Weight:534.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (289 KB)

Filanesib TFA Chemical Structure

CAS No.: 1781834-99-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 6 nM (KSP)^[1]

All Kinesin Isoforms :

In Vitro

Filanesib TFA induces mitotic arrest in multiple cell lines^[1].
Filanesib TFA exhibits anti-proliferative against a broad range of human and rodent tumor cell lines, including a variety of leukemias and solid tumors, with EC₅₀s between 0.4 nM and 14.4 nM^[1].
Filanesib (0.001-0.1 nM; 36 hours) TFA induces apoptosis in a dose-dependent manner in HeLa cells^[1].
Filanesib (3.13-6.25 nM; 44 hours) TFA causes accumulation of cells in the G2/M phase of the cell cycle in a dose-dependent manner in HeLa cells^[1].
Filanesib TFA potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway and has potential to eradicate AML progenitor cells^[2].
Filanesib (3 μM; 6-24 hours) TFA is able to induce caspase-2 activation^[3].
Filanesib (0.003-3 μM; 24-48 hours) TFA is cytotoxic in Type II EOC cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Filanesib (20 mg/kg, 30 mg/kg; i.p.; q4dx3) TFA has anti-tumor activitiy in vivo^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 1781834-99-8
Molecular Weight 534.50
Formula C₂₂H₂₃F₅N₄O₄S
SMILES

O=C(N1[C@@](C2=CC=CC=C2)(CCCN)SC(C3=CC(F)=CC=C3F)=N1)N(OC)C.OC(C(F)(F)F)=O
Synonyms

ARRY-520 TFA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (7)

All Cell Proliferation/Viability AssayFlow CytometryApoptosis AnalysisIn Vivo Efficacy StudyIF

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Cell Discov

Single-cell profiling reveals molecular basis of malignant phenotypes and tumor microenvironments in small bowel adenocarcinomas. [Abstract]

2022 Sep 14;8(1):92. PMID: 36104333

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cell Discov. 2022 Sep 14;8(1):92. [Abstract]

Filanesib (0-100 μM; 36 h) inhibited HUTU-80 cell survival in a dose-dependent manner.
Cancer Lett

KIF11 inhibitors filanesib and ispinesib inhibit meningioma growth in vitro and in vivo. [Abstract]

2021 May 28:506:1-10. PMID: 33652084

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]

Filanesib (0-10 nM; 48 h) showed antiproliferative effects in the benign meningioma cell line Ben-Men-1 and the anaplastic cell lines NCH93, IOMM-Lee, and KT21-MG cells.

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]

Filanesib (10 nM; 24, 48, 72 h) induced cell cycle arrest at G2/M-phase in Ben-Men-1, NCH93, IOMM-Lee, and KT21-MG cells.

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]

Filanesib (10 nM; 72 h) induced cell apoptosis in Ben-Men-1, NCH93, IOMM-Lee, and KT21-MG cells.

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]

Filanesib (10 mg/kg; i.p.; once every three days on five occasions) inhibited NCH93 tumor growth in NCH93 tumor-bearing mice.

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]

Filanesib (10 mg/kg; i.p.; once every three days on five occasions) showed a significant reduction of Ki-67-positive cells in tumor sections.
NPJ Precis Oncol

Functional screening identifies kinesin spindle protein inhibitor filanesib as a potential treatment option for hepatoblastoma. [Abstract]

2025 Apr 25;9(1):122. PMID: 40281281
Gene

Targeting Eg5 using Arry520 combats gastric cancer by inducing monopolar spindles. [Abstract]

2025 Jul 5:955:149458. PMID: 40187619
Preprints

2023 Sep 30.
University of Leicester

June 2023.
Methods Mol Biol

Methods for High-throughput Drug Combination Screening and Synergy Scoring. [Abstract]

2018:1711:351-398. PMID: 29344898

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (289 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Christine Lemieux, et al. ARRY-520, a Novel, Highly Selective KSP Inhibitor with Potent Anti-Proliferative Activity. AACR Annual Meeting. 2007.

[2]. BZ Carter, et al. Inhibition of KSP by ARRY-520 Induces Cell Cycle Block and Cell Death via the Mitochondrial Pathway in AML Cells. [Content Brief]

[3]. Ki Hyung Kim, et al. KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells. J Transl Med. 2009; 7: 63. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Filanesib TFA

7 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Purity & Documentation
References

1/16
1/16

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cell Discov. 2022 Sep 14;8(1):92. [Abstract]

Customer Validation
Filanesib (0-100 μM; 36 h) inhibited HUTU-80 cell survival in a dose-dependent manner.
1/16

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]

Customer Validation
Filanesib (0-10 nM; 48 h) showed antiproliferative effects in the benign meningioma cell line Ben-Men-1 and the anaplastic cell lines NCH93, IOMM-Lee, and KT21-MG cells.
1/16

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]

Customer Validation
Filanesib (10 nM; 24, 48, 72 h) induced cell cycle arrest at G2/M-phase in Ben-Men-1, NCH93, IOMM-Lee, and KT21-MG cells.
1/16

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]

Customer Validation
Filanesib (10 nM; 72 h) induced cell apoptosis in Ben-Men-1, NCH93, IOMM-Lee, and KT21-MG cells.
1/16

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]

Customer Validation
Filanesib (10 mg/kg; i.p.; once every three days on five occasions) inhibited NCH93 tumor growth in NCH93 tumor-bearing mice.
1/16

Filanesib TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]

Customer Validation
Filanesib (10 mg/kg; i.p.; once every three days on five occasions) showed a significant reduction of Ki-67-positive cells in tumor sections.

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Filanesib TFA

Publications Citing Use of MedChemExpress (MCE) Filanesib TFA

All Kinesin Isoforms