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Cat. No.: HY-187649

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FLAD1-IN-1

FLAD1-IN-1 is a FLAD1 inhibitor. FLAD1-IN-1 impairs the activity of mitochondrial complex II by disrupting the intracellular FAD pool, thereby inducing cellular mitochondrial dysfunction and reducing hypoxic tolerance. FLAD1-IN-1 exhibits anticancer activity against hypoxic tumors. FLAD1-IN-1 can be used in the research of lung cancer.

For research use only. We do not sell to patients.

CAS No.: 2696100-70-4
Formula: C₂₃H₂₂N₂O₅
Molecular Weight:406.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FLAD1-IN-1 Chemical Structure

CAS No.: 2696100-70-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Anti-cancerOthers

Anti-cancer

FLAD1-IN-1 (~1-~100 μM; 48 h) selectively inhibits the viability of hypoxic PC9 lung cancer cells with greater potency than in normoxic PC9 cells^[1].

Others

FLAD1-IN-1 (Compound C4-31) directly inhibits wild-type recombinant FLAD1 protein activity, with its binding dependent on the FLAD1^G487 residue of FLAD1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC9 human lung cancer cells
Concentration:

~1-~100 μM
Incubation Time:

48 h
Result:

Selectively inhibited the viability of hypoxic PC9 cells compared to normoxic PC9 cells.
Exhibited a lower IC₅₀ under hypoxic conditions.

Related Protocols :

Mitochondrial membrane-potential and mitochondrial mass staining

Chemical Information

CAS No. 2696100-70-4
Molecular Weight 406.43
Formula C₂₃H₂₂N₂O₅
SMILES

CCOC(COC1=C(C=C(C=C1)/C=N\NC(C2=CC3=C(C=C2)C=CC=C3)=O)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhao X, et al. Deep learning reveals FLAD1-mediated mitochondrial metabolic reprogramming in hypoxic tumors. Cell reports. 2026 Jul 28;45(7):117711.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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