Fladrafinil
Based on 1 Customer Validation
Fladrafinil (CRL-40,941) is an orally active analog of Modafinil and a wake-promoting agent. Fladrafinil is a prodrug that is metabolized in vivo to Flmodafinil, which further generates Flmodafinil acid and Flmodafinil sulfone. Fladrafinil can be used in research related to neurological diseases.
For research use only. We do not sell to patients.
- Purity : 98.74%
- CAS No.: 90212-80-9
- Formula: C15H13F2NO3S
- Molecular Weight:325.33
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Fladrafinil (CRL-40,941) undergoes pyrolysis to generate 1,1,2,2-tetrakis (4-fluorophenyl) ethane as well as the para-fluoro analogs of diphenylmethane, benzophenone, and benzhydrol[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 90212-80-9
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Appearance Solid
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Molecular Weight 325.33
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Formula C15H13F2NO3S
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Color White to off-white
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SMILES
O=C(NO)CS(C(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2)=O
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Synonyms
CRL-40,941
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (307.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[2]. Dowling G, et al. Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector: formation of 1,1,2,2-tetraphenylethane and its tetra fluoro analog. Drug testing and analysis. 2017 Mar;9(3):518-528. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0738 mL | 15.3690 mL | 30.7380 mL | 76.8451 mL |
| 5 mM | 0.6148 mL | 3.0738 mL | 6.1476 mL | 15.3690 mL | |
| 10 mM | 0.3074 mL | 1.5369 mL | 3.0738 mL | 7.6845 mL | |
| 15 mM | 0.2049 mL | 1.0246 mL | 2.0492 mL | 5.1230 mL | |
| 20 mM | 0.1537 mL | 0.7685 mL | 1.5369 mL | 3.8423 mL | |
| 25 mM | 0.1230 mL | 0.6148 mL | 1.2295 mL | 3.0738 mL | |
| 30 mM | 0.1025 mL | 0.5123 mL | 1.0246 mL | 2.5615 mL | |
| 40 mM | 0.0768 mL | 0.3842 mL | 0.7685 mL | 1.9211 mL | |
| 50 mM | 0.0615 mL | 0.3074 mL | 0.6148 mL | 1.5369 mL | |
| 60 mM | 0.0512 mL | 0.2562 mL | 0.5123 mL | 1.2808 mL | |
| 80 mM | 0.0384 mL | 0.1921 mL | 0.3842 mL | 0.9606 mL | |
| 100 mM | 0.0307 mL | 0.1537 mL | 0.3074 mL | 0.7685 mL |
Fladrafinil Related Classifications
HY-129048 Related Classifications
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