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Cat. No.: HY-W367959

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Flunamine

Flunamine is a broad-spectrum monoamine transporter inhibitor that inhibits the uptake of dopamine (DA), 5-hydroxytryptamine (5-HT), and noradrenaline (NA) in rat brain synaptosomes. The IC₅₀ values of Flunamine for DA and 5-HT uptake in rat striatal synaptosomes are 0.26 μM and 0.17 μM, respectively, and the IC₅₀ values for 5-HT and NA uptake in hypothalamic synaptosomes are 0.24 μM and 0.092 μM, respectively. Flunamine acts through broad-spectrum inhibition of dopaminergic, serotonergic, and noradrenergic monoamine reuptake and is used in research related to depression and Parkinson's disease.

For research use only. We do not sell to patients.

CAS No.: 50366-32-0
Formula: C₁₅H₁₅F₂NO
Molecular Weight:263.29

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Please store the product under the recommended conditions in the Certificate of Analysis.

Flunamine Chemical Structure

CAS No.: 50366-32-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target

^[2]

DAT

0.26 μM (IC₅₀)

SERT

0.17 μM (IC₅₀)

SERT

0.24 μM (IC₅₀)

NET

0.092 μM (IC₅₀)

In Vitro

Flunamine (preincubation for 10 min; uptake incubation for 5 min) inhibits DA and 5-HT uptake in rat striatal synaptosomes with IC₅₀ values of 0.26 μM and 0.17 μM, respectively^[2].
Flunamine (preincubation for 10 min; uptake incubation for 5 min) inhibits the uptake of 5-HT and NA in rat hypothalamic synaptosomes, with IC₅₀ values of 0.24 μM and 0.092 μM, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Human pluripotent stem cell midbrain dopaminergic neuron differentiation

Chemical Information

CAS No. 50366-32-0
Molecular Weight 263.29
Formula C₁₅H₁₅F₂NO
SMILES

FC1=CC=C(C=C1)C(OCCN)C2=CC=C(F)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gootjes J. Aminoalkylethers. US, US4003932A. 1977-01-18.

[2]. Van der Zee P, et al. A comparison of the inhibitory effects of aromatic substituted benzhydryl ethers on the uptake of catecholamines and serotonin into synaptosomal preparations of the rat brain. Neuropharmacology. 1978;17(7):483-490.

[3]. Mueller A, et al. Methods and compounds for treating depression and other disorders. WO, WO0002551A2. 2000-01-20.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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