Folate-PEG3-alkyne
Based on 1 Customer Validation
Folate-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Folate-PEG3-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity : 97.70%
- CAS No.: 1245285-73-7
- Formula: C28H34N8O8
- Molecular Weight:610.62
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
Description
IC50 & Target
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PEGs |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1245285-73-7
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Appearance Solid
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Molecular Weight 610.62
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Formula C28H34N8O8
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Color Light yellow to yellow
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SMILES
NC(NC1=O)=NC2=C1N=C(C=N2)CNC3=CC=C(C(N[C@@H](CCC(NCCOCCOCCOCC#C)=O)C(O)=O)=O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (81.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.6377 mL | 8.1884 mL | 16.3768 mL | 40.9420 mL |
| 5 mM | 0.3275 mL | 1.6377 mL | 3.2754 mL | 8.1884 mL | |
| 10 mM | 0.1638 mL | 0.8188 mL | 1.6377 mL | 4.0942 mL | |
| 15 mM | 0.1092 mL | 0.5459 mL | 1.0918 mL | 2.7295 mL | |
| 20 mM | 0.0819 mL | 0.4094 mL | 0.8188 mL | 2.0471 mL | |
| 25 mM | 0.0655 mL | 0.3275 mL | 0.6551 mL | 1.6377 mL | |
| 30 mM | 0.0546 mL | 0.2729 mL | 0.5459 mL | 1.3647 mL | |
| 40 mM | 0.0409 mL | 0.2047 mL | 0.4094 mL | 1.0235 mL | |
| 50 mM | 0.0328 mL | 0.1638 mL | 0.3275 mL | 0.8188 mL | |
| 60 mM | 0.0273 mL | 0.1365 mL | 0.2729 mL | 0.6824 mL | |
| 80 mM | 0.0205 mL | 0.1024 mL | 0.2047 mL | 0.5118 mL |
Folate-PEG3-alkyne Related Classifications
HY-133496 Related Classifications
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