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Cat. No.: HY-184096

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Forazapadin

Name: Forazapadin
Brand: MedChemExpress
SKU: HY-184096
Availability: PreOrder

(Synonyms: Forazapadinum)

Forazapadin (Forazapadinum) is a AAK1 inhibitor that inhibits AAK1, BIKE, and GAK. Forazapadin can be used in research related to AAK1-mediated diseases and muscle disorders.

For research use only. We do not sell to patients.

CAS No.: 3061827-86-6
Formula: C₂₄H₂₇N₇O₄
Molecular Weight:477.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Forazapadin Chemical Structure

CAS No.: 3061827-86-6

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

Forazapadin (Forazapadinum) is a AAK1 inhibitor that inhibits AAK1, BIKE, and GAK. Forazapadin can be used in research related to AAK1-mediated diseases and muscle disorders^[1].

In Vitro

Forazapadin (I-34) exhibits potent in vitro biochemical inhibitory activity against AAK1 (AAK1 pSEN EIC₅₀ = 1-50 nM), and moderately inhibits intracellular AAK1 as detected by Western blotting (intracellular AAK1 IC₅₀ = 151-500 nM). It shows moderate inhibitory activity against BIKE (BIKE pSEN IC₅₀ = 151-500 nM), extremely weak inhibitory activity against GAK (GAK pSEN IC₅₀ > 1500 nM), and displays optimal targeting preference for AAK1 over GAK^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3061827-86-6
Molecular Weight 477.52
Formula C₂₄H₂₇N₇O₄
SMILES

O=C(N(C1)C)C[C@@H]1OC(N(CC2)CCN2C3=NC(N(C=C3)N=C4)=C4C(C=CC=N5)=C5OC6CC6)=O
Synonyms

Forazapadinum
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jaquith J B. Ap2 associated kinase 1 inhibitors and uses thereof. WO2025054448A1. WIPO. 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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