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Cat. No.: HY-133806

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Fumarranol

Fumarranol, a Fumagillin (HY-B0751) analogue, is a selective type 2 methionine aminopeptidase (MetAP2) inhibitor with a human IC₅₀ of 3.2 μM. Fumarranol inhibits proliferation of bovine aortic endothelial cells and inhibits angiogenesis in a mouse matrigel plug model. Fumarranol can be used for the researches of cancer, diabetic retinopathy, age-related macular degeneration.

For research use only. We do not sell to patients.

CAS No.: 912569-37-0
Formula: C₁₆H₂₄O₄
Molecular Weight:280.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fumarranol Chemical Structure

CAS No.: 912569-37-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

MetAp2

3.2 μM (IC₅₀)

All MetAP Isoforms :

All VEGFR Isoforms :

In Vitro

Fumarranol (0-100 μM) selectively inhibits recombinant hMetAP2 enzymatic activity with an IC₅₀ of 3.2 μM, and does not inhibit hMetAP1 at 100 μM^[1].
Fumarranol inhibits bovine aortic endothelial cell proliferation with an IC₅₀ of 34 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fumarranol (90 mg/kg) blocks the growth of new blood vessels in mice with , matrigel containing VEGF and basic FGF^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 912569-37-0
Molecular Weight 280.36
Formula C₁₆H₂₄O₄
SMILES

O(C)[C@]12[C@](CO)([C@]1([C@]3(C)[C@@H](CC=C(C)C)O3)[H])CCC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lu J, et al. Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo. J Med Chem. 2006 Sep 21;49(19):5645-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Fumarranol

All MetAP Isoforms

All VEGFR Isoforms