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Cat. No.: HY-N19916

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Fumiquinazoline A

Fumiquinazoline A is a peptidyl quinazolinone indole alkaloid isolated from Aspergillus fumigatus, with antifungal activity. Fumiquinazoline A serves as a substrate for the flavoenzyme Af12070 and FAD-dependent amide oxidase Af12070, which oxidizes it into the seven-membered spiroaminal Fumiquinazoline C. Fumiquinazoline A is applicable to studies related to fungal infections.

For research use only. We do not sell to patients.

CAS No.: 140715-85-1
Formula: C₂₄H₂₃N₅O₄
Molecular Weight:445.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fumiquinazoline A Chemical Structure

CAS No.: 140715-85-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

Fungal InfectionOthers

Fungal Infection

Fumiquinazoline A (compound 2) exhibits moderate antifungal activity against phytopathogenic fungi, with an MIC value of 12.5-25 μg/mL, and its activity is stronger than that of Fumiquinazoline D (HY-125523)^[3].

Others

Fumiquinazoline A serves as a substrate for the FAD-dependent oxidase Af12070 Δ1-24, which drives O₂ consumption with an apparent turnover number of 4.6 min^-1^[1].
Fumiquinazoline A (200 µM; 0.1-20 hrs) is oxidized by Af12070 Δ1-24 to form the seven-membered spiroaminal Fumiquinazoline C^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 140715-85-1
Molecular Weight 445.47
Formula C₂₄H₂₃N₅O₄
SMILES

O[C@@]1([C@]2([H])N(C([C@@H](N2)C)=O)C3=CC=CC=C31)C[C@H]4N5C([C@@H](NC4=O)C)=NC6=CC=CC=C6C5=O
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Microorganism
Aspergillus fumigatus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ames BD, et al. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 2011 Oct 11;50(40):8756-69. [Content Brief]

[2]. An CY, et al. Aniquinazolines A-D, four new quinazolinone alkaloids from marine-derived endophytic fungus Aspergillus nidulans. Marine drugs. 2013 Jul 23;11(7):2682-94. [Content Brief]

[3]. Resende D I S P, et al. Chemistry of the fumiquinazolines and structurally related alkaloids. Natural Product Reports, 2019, 36(1): 7-34.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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