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Cat. No.: HY-189955

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GBM CSCs-IN-2

GBM CSCs-IN-2 is a GBM CSCs growth inhibitor with blood-brain barrier penetration capability. GBM CSCs-IN-2 activates ASIC3 through an ASIC3 binding pocket that overlaps with GMQ, chronically activating this proton-gated Na⁺ channel, thereby inhibiting cancer stem cell growth without reducing the viability of cells lacking ASIC3. GBM CSCs-IN-2 can be used in research related to glioblastoma.

For research use only. We do not sell to patients.

Formula: C₁₁H₁₃ClN₆
Molecular Weight:264.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GBM CSCs-IN-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Sodium Channel Isoforms :

In Vitro

Anti-cancerOthers

Anti-cancer

GBM CSCs-IN-2 (compound 1a) (10 µM; 72 h) inhibits MES-0315 GBM CSC 3D neurosphere growth^[1].

Others

GBM CSCs-IN-2 (10 µM; 72 h) shows no obvious cytotoxicity in ASIC3-deficient CHO-K1 cells^[1].
GBM CSCs-IN-2 shows predicted low cardiac ion channel toxicity and moderate nephrotoxicity risk through computational ADMET analysis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MES-0315 GBM CSCs
Concentration:

10 µM
Incubation Time:

72 h
Result:

MES-0315 GBM CSC 3D neurosphere growth was inhibited by 42.4% at 10 µM.

Related Protocols :

Parmacokinetics

Species	Dose	Route	B/P
Mice^[1]	2 mg/kg	i.v.	25.4 %

Chemical Information

Molecular Weight 264.71
Formula C₁₁H₁₃ClN₆
SMILES

NC(N/N=C/C1=NC2=CC=CC=C2C(C)=N1)=N.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Maiorana L, et al. A Blood-Brain Barrier-Permeable Guanylhydrazone Analogue of the ASIC3 Activator GMQ Inhibits Human Glioblastoma Stem Cell Growth In Vitro. ChemMedChem. 2026 Sep 28;21(18):e70438.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

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100 mg

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