GCC-2
GCC-2 is a glycolipid. GCC-2 binds to CD1d and presents it to cells. GCC-2 induces Th1-biased cellular activation and IFN-γ production. GCC-2 inhibits antitumor activity in colon cancer tumor models and induces antigen-specific humoral immune responses. GCC-2 can be used for research on colon adenocarcinoma.
For research use only. We do not sell to patients.
- Formula: C54H97NO10
- Molecular Weight:920.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CD1d |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse splenocytes
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Concentration:1-1000 nM
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Incubation Time:72 h
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Result:Exhibited maximal activities 17.8-fold higher than αGalCer.
Maintained Th1-biased cytokine profiles across the 1 to 1000 nM concentration range.
Induced higher IFN-γ levels and stronger Th1 polarization than branched analogs 16 and 17.
Pretreatment with an anti-CD1d monoclonal antibody significantly suppressed cytokine secretion.
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Cell Line:DC2.4 cells
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Concentration:100 nM
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Incubation Time:2, 6, 12, 18, or 24 h
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Result:Exhibited markedly enhanced L363 signals at 12, 18, and 24 h compared with αGalCer.
Showed the strongest L363 signals in DC2.4 cells after 18 h of treatment.
In Vivo
GCC-2 (i.p.) more effectively activates innate immune responses in mice, enhances coordinated NKT and NK cell activation, and promotes Th1-biased responses in vivo[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (strain not specified)[1]
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Dosage:2.33 nmol
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Administration:i.p.
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Result:Increased IFN-γ secretion by ∼12-fold relative to αGalCer and 28-fold relative to its linear analog 3.
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Animal Model:BALB/c mice[1]
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Dosage:1 nmol
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Administration:i.v.; on days 3 and 10
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Result:Reduced average tumor volume to approximately 500 mm3 on day 30.
Significantly prolonged survival relative to αGalCer.
Significantly increased IFN-γ production relative to αGalCer.
Chemical Information
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Molecular Weight 920.35
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Formula C54H97NO10
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SMILES
OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@@H]1OC[C@H](NC(CCC2=CC=CC(OCC3CCCCCCCCCCCCCCCCCC3)=C2)=O)[C@H](O)[C@@H](CCCCCCCCCCCCCCC)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GCC-2 Related Classifications
HY-189459 Related Classifications
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