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Cat. No.: HY-184266

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GCLCi0

Name: GCLCi0
Brand: MedChemExpress
SKU: HY-184266
Availability: PreOrder

(Synonyms: ONO-6428513)

GCLCi0 (ONO-6428513) is a glutamate-cysteine ligase catalytic subunit (GCLC) inhibitor and ferroptosis inducer that blocks the rate-limiting step of glutathione synthesis and exerts anti-tumor activity. GCLCi0 specifically targets SMARCB1-deficient cancer cells, induces reactive oxygen species production and lipid peroxidation. In addition, GCLCi0 shows a significant synergistic effect with SLC7A11 inhibitors and Telaglenastat (HY-12248). GCLCi0 can be used in the research of smarcb1-deficient malignant rhabdoid tumors and smarcb1-deficient epithelioid sarcomas.

For research use only. We do not sell to patients.

CAS No.: 2926699-71-8
Formula: C₈H₁₅F₃N₂O₃S
Molecular Weight:276.28

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Please store the product under the recommended conditions in the Certificate of Analysis.

GCLCi0 Chemical Structure

CAS No.: 2926699-71-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

In Vitro

Anti-cancerFerroptosis

Anti-cancer

GCLCi0 (72 h) potently and selectively inhibits the viability of SMARCB1-deficient rhabdoid tumor cells (JMU-RTK-2, G401, G402) with significantly lower IC₅₀ values than in SMARCB1-proficient renal cancer cells, displaying a selective index superior to approved EZH2 inhibitors^[1].

Anti-cancer

GCLCi0 (0.1-10 μM; 24-48 h) selectively depletes the GSH/GSSG ratio in SMARCB1-deficient rhabdoid tumor cells (JMU-RTK-2, G401, G402) in a concentration-dependent manner, with minimal effect on SMARCB1-proficient renal cancer cells^[1].

Ferroptosis

GCLCi0 (0.1-4 μM; 72 h) selectively induces concentration-dependent lipid peroxidation in SMARCB1-deficient rhabdoid tumor cells (JMU-RTK-2, G401), an effect that is suppressed by the ferroptosis inhibitor Ferrostatin-1 (HY-100579)^[1].

Ferroptosis

GCLCi0 (72 h) antiproliferative effect on SMARCB1-deficient JMU-RTK-2 rhabdoid tumor cells is rescued by the ferroptosis inhibitor ferrostatin-1 but not by the apoptosis inhibitor Z-VAD-FMK, confirming ferroptosis as the mechanism of cell death^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 2926699-71-8
Molecular Weight 276.28
Formula C₈H₁₅F₃N₂O₃S
SMILES

N[C@H](C(O)=O)CCS(=N)(CCCC(F)(F)F)=O
Synonyms

ONO-6428513
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Takeuchi M, et al.. A GCLC Inhibitor Enhances the Antitumor Efficacy of Glutathione Metabolic Pathway Inhibition in SMARCB1-Deficient Rhabdoid Tumors. Cancer research. 2026 Jun 15;86(12):2990-3004. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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