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Cat. No.: HY-208758A

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GCN2-IN-8

(S)-GCN2-IN-8 is a general control nonderepressible 2 (GCN2, EIF2AK4) inhibitor. (S)-GCN2-IN-8 inhibits signal transduction by the stress response kinase GCN2. (S)-GCN2-IN-8 can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 1627177-37-0
Formula: C₂₀H₂₀N₈O
Molecular Weight:388.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GCN2-IN-8 Chemical Structure

CAS No.: 1627177-37-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Protein/Amino Acid Metabolism

(S)-GCN2-IN-8 ( compound A88) inhibits GCN2 enzyme activity in a cell-free biochemical assay, categorized as class B potency^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1627177-37-0
Molecular Weight 388.43
Formula C₂₀H₂₀N₈O
SMILES

COC1=CC=C(N2N=NC3=C2N=C(N[C@H]4CCN(C5=CC=NC=C5)C4)N=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dorsch, D, et al. Triazolo[4,5-d]pyrimidine derivatives for the treatment of diseases such as cancer. PCT/EP2014/000361. WIPO. 2014-09-12.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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