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Cat. No.: HY-N20676

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Geministatin D

Geministatin D is a derivative of Geministatin A that retains the C17 (Z,Z)-diene alkyl side chain but lacks the complete diester backbone. As a chemical degradation fragment of the parent compound, Geministatin D shows weak antibacterial activity against Gram-positive bacteria but exerts mild inhibitory effects on Saccharomyces cerevisiae. Geministatin D can be used in studies on fungal infections caused by Saccharomyces cerevisiae.

For research use only. We do not sell to patients.

CAS No.: 3131756-58-3
Formula: C₃₀H₄₆O₉
Molecular Weight:550.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Geministatin D Chemical Structure

CAS No.: 3131756-58-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

Anti-cancerBacterial InfectionFungal Infection

Anti-cancer

Geministatin D exhibits cytotoxicity against mouse myeloma NS-1 cells with an IC₅₀ of 68 μM, but shows no significant cytotoxicity toward neonatal foreskin fibroblasts even at concentrations as high as 180 μM^[1].

Bacterial Infection

Geministatin D inhibits the growth of Bacillus subtilis with an MIC of 25 μg/mL; however, it shows no inhibitory effect on the growth of Staphylococcus aureus or methicillin-resistant Staphylococcus aureus even at concentrations as high as 100 μg/mL^[1].

Fungal Infection

Geministatin D inhibits the growth of Saccharomyces cerevisiae with an MIC of 13 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3131756-58-3
Molecular Weight 550.68
Formula C₃₀H₄₆O₉
SMILES

O[C@H]1[C@H](OC2=CC(CCCCCCC/C=C\C/C=C\CCCCC)=C(C(O)=O)C(O)=C2)O[C@H](CO)[C@H](O)[C@@H]1O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganism
Austroacremonium gemini
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Crombie A, et al. Geministatins: new depside antibiotics from the fungus Austroacremonium gemini. The Journal of antibiotics. 2024 Oct;77(10):639-646. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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