HOTAIR - HOX transcript antisense RNA Gene
Also Known as HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072
Species: Homo sapiens
About HOTAIR
This gene has 6 transcripts (splice variants). Biased expression in testis (RPKM 1.6), skin (RPKM 1.2) and 6 other tissues.
Summary
This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with the HOXC genes. It functions through an RNA product, which binds lysine specific demethylase 1 (LSD1) and Polycomb repressive complex 2 (PRC2), and serves as a scaffold to assemble these regulators at the HOXD gene cluster, thereby promoting epigenetic repression of HOXD. This gene is highly expressed in multiple Tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2019]
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Osteoarthritis |
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| Gastrointestinal System Cancer |
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| Kidney Cancer |
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| Gastric Adenocarcinoma |
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| Cerebrovascular Disease |
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| Triple-Receptor Negative Breast Cancer |
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| Skin Squamous Cell Carcinoma |
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| Functionless Pituitary Adenoma |
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| Lemierre'S Syndrome |
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| Gastric Cardia Adenocarcinoma |
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| Congestive Heart Failure |
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| Leukemia |
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| Retinoblastoma |
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| High Grade Glioma |
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| Embryonal Carcinoma |
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| Pancreatic Ductal Adenocarcinoma |
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| Sarcoma |
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| Bladder Urothelial Carcinoma |
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| Pre-Eclampsia |
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| Hepatitis C |
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| Laryngeal Squamous Cell Carcinoma |
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| Liver Cirrhosis |
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| Cellular Ependymoma |
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| Pregnancy Loss, Recurrent 1 |
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| B-Cell Lymphoma |
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| Oral Squamous Cell Carcinoma |
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| Atypical Teratoid Rhabdoid Tumor |
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| Squamous Cell Carcinoma |
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| Pituitary Adenoma |
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| Nasopharyngeal Carcinoma |
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| Small Cell Cancer Of The Lung |
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| Lung Cancer Susceptibility 3 |
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| Gastrointestinal Stromal Tumor |
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| Gallbladder Cancer |
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| Squamous Cell Carcinoma, Head And Neck |
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| Diffuse Large B-Cell Lymphoma |
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| Leukemia, Chronic Myeloid |
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| Cervical Cancer |
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| Rheumatoid Arthritis |
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| Esophagus Squamous Cell Carcinoma |
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| Glioblastoma |
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| Thyroid Carcinoma |
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| Endometrial Cancer |
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| Neuroblastoma |
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| Myeloma, Multiple |
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| Osteogenic Sarcoma |
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| Esophageal Cancer |
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| Thyroid Cancer, Nonmedullary, 1 |
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| Bladder Cancer |
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| Heart Disease |
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| Medulloblastoma |
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| Ovarian Epithelial Cancer |
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| Glioma |
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| Renal Cell Carcinoma, Nonpapillary |
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| Parkinson Disease, Late-Onset |
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| Pancreatic Cancer |
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| Melanoma |
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| Leukemia, Acute Myeloid |
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| Gastric Cancer |
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| Ovarian Cancer |
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| Hepatocellular Carcinoma |
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| Prostate Cancer |
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| Lung Cancer |
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| Colorectal Cancer |
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| Breast Cancer |
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| Retinitis Pigmentosa 11 |
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| Autism Spectrum Disorder |
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| Retinitis Pigmentosa |
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