Pah - phenylalanine hydroxylase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18478

Summary

Enables phenylalanine 4-monooxygenase activity. Predicted to be involved in L-phenylalanine metabolic process; protein hydroxylation; and tyrosine biosynthetic process, by oxidation of phenylalanine. Predicted to act upstream of or within L-phenylalanine catabolic process. Is expressed in alimentary system; liver; and liver lobe. Used to study Phenylketonuria. Human ortholog(s) of this gene implicated in intellectual disability and Phenylketonuria. Orthologous to human PAH (phenylalanine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Pah Products (1)

mRNA Protein Name
NM_008777.3 NP_032803.2 phenylalanine-4-hydroxylase
Protein Preferred Names Protein Names

phenylalanine-4-hydroxylase

  • phe-4-monooxygenase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0124A Sapropterin dihydrochloride 99.82% Yes
HY-14184 Macitentan 99.87% Yes
HY-P0012 Aviptadil Inhibitor 99.95% Unkown
HY-A0126A Epoprostenol sodium Inducer 98.03% Unkown
HY-P0012A Aviptadil acetate Inhibitor 99.87% Unkown
HY-109013 Sofpironium bromide Inhibitor 98.26% Unkown
HY-A0124AR Sapropterin dihydrochloride (Standard) 99.96% Unkown
HY-A0124 Sapropterin / Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-A0126AR Epoprostenol sodium (Standard) / Phase 4
HY-15472 PRX-08066 97.46% Phase 2
HY-101124 Rodatristat ethyl Inhibitor 99.82% Phase 2
HY-B1727 Phenanthrene 99.82% Phase 1
HY-129851 NTP42 Antagonist 98.58% Phase 1
HY-170435 PDE5-IN-13 Inhibitor / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990733 Cibotercept Inhibitor 99.85% Phase 2
HY-P992008 PF-07868489 ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (52)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W011845 DMBA Inducer 99.94% Unkown
HY-103609 Pyrene 99.89% Unkown
HY-W014075 1-Hydroxypyrene 99.76% Unkown
HY-W026772 Fluorene 99.35% Unkown
HY-121107 Chrysene 99.81% Unkown
HY-111450 CB7993113 Antagonist 98.0% Unkown
HY-W016103 1-Hydroxy-2-naphthoic acid 99.78% Unkown
HY-W013570 Acenaphthylene 99.62% Unkown
HY-B1727S Phenanthrene-d10 99.46% Unkown
HY-14184S Macitentan-d4 99.85% Unkown
HY-N11222 Nonanoylcarnitine 99.94% Unkown
HY-W012278 Benz[a]anthracene Ligand 99.90% Unkown
HY-128593 TPN171 Inhibitor 98.10% Unkown
HY-121107S Chrysene-d12 99.71% Unkown
HY-W014075S 1-Hydroxypyrene-d9 99.95% Unkown
HY-14184A Macitentan n-butyl analogue 99.35% Unkown
HY-177948 GRK2 degrader-1 Degrader 98.83% Unkown
HY-23498 Benzo[k]fluoranthene / Unkown
HY-RS09979 PAH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W026772S Fluorene-d10 99.0% Unkown
HY-W026772S1 Fluorene-d8 / Unkown
HY-131973 PDE10A-IN-2 hydrochloride Inhibitor 98.43% Unkown
HY-174416 Smurf1-IN-5 Inhibitor 99.01% Unkown
HY-P3242 Mad1 (6-21) 98.02% Unkown
HY-W585976 Benzo[a]pyrene diol epoxide 93.0% Unkown
HY-144856S1 Sapropterin-d3 / Unkown
HY-33451 4-Dibenzofurancarboxylic acid 99.92% Unkown
HY-W012278S Benz[a]anthracene-d12 Ligand 99.74% Unkown
HY-W013570S Acenaphthylene-d8 99.48% Unkown
HY-W017708 Triphenylene 99.30% Unkown
HY-W777456 Phenanthrene-13C6 99.9% Unkown
HY-109013S Sofpironium-13C,d3 bromide Inhibitor / Unkown
HY-115477 Brilaroxazine hydrochloride / Unkown
HY-149492 Phosphatase-IN-1 Inhibitor 99.88% Unkown
HY-15472A PRX-08066 maleate / Unkown
HY-155737 ET receptor antagonist 1 Inhibitor / Unkown
HY-155738 ET receptor antagonist 2 Inhibitor / Unkown
HY-155739 ET receptor antagonist 3 Inhibitor / Unkown
HY-167849 Sofpironium tosylate Inhibitor / Unkown
HY-167906S Hexadecyl 2-((4-Nitrophenyl)thio)acetate-13C2 / Unkown
HY-168178 Hsp110-STAT3 PPI-IN-2 Inhibitor / Unkown
HY-D1549 o-Pah / Unkown
HY-N10021 Benzo[e]pyrene 98.0% Unkown
HY-P3242A Mad1 (6-21) TFA / Unkown
HY-W777458 Fluorene-13C6 / Unkown
HY-W778162 Phenanthrene-13C2 / Unkown
HY-167906 Lunamarine Inhibitor / Unkown
HY-172508 Perylene dU phosphoramidite / Unkown
HY-19197 2-NAP / Unkown
HY-RS17018 Pah Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23461 Pah Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W016103R 1-Hydroxy-2-naphthoic acid (Standard) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pah NCBI NCBI:5053