BACE2 - beta-secretase 2 Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 478418

About BACE2

Primary_assembly 31: 35,196,852-35,277,649 forward strand.ROS_Cfam_1.0:CM025130.1

This gene has 1 transcript (splice variant), 214 orthologues and 10 paralogues.

BACE2 Products (1)

mRNA Protein Name
XM_038443555.1 XP_038299483.1 beta-secretase 2

BACE2 Protein Structure

beta_secretase_like

beta_secretase_like: cd05473 (78 - 439)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

beta-secretase 2

  • beta-site APP-cleaving enzyme 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-16759 Verubecestat Inhibitor 99.56% Phase 3
HY-119689 Umibecestat Inhibitor 99.81% Phase 3
HY-100182 BACE1-IN-1 Inhibitor 98.72% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136742 BACE2-IN-1 Inhibitor 99.4% Unkown
HY-124322 NB-360 Inhibitor 99.08% Unkown
HY-12938 AMG-8718 Inhibitor / Unkown
HY-100182A BACE1-IN-1 hydrochloride Inhibitor / Unkown
HY-147758 BACE1/2-IN-1 Inhibitor / Unkown
HY-161359 BACE1-IN-14 Inhibitor / Unkown
HY-119689A Umibecestat hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens BACE2 NCBI NCBI:25825