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Cat. No.: HY-N19212

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Glenthmycin A

Glenthmycin A is a macrocyclic type II spiroketal polyketide antibacterial agent. Glenthmycin A inhibits the growth of Gram-positive pathogens. Glenthmycin A is applicable to the research of bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 3040055-59-9
Formula: C₄₉H₆₃NO₁₃
Molecular Weight:874.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Glenthmycin A Chemical Structure

CAS No.: 3040055-59-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H460	IC₅₀	30 μM Compound: 1	Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay	[PMID: 35640100]
SW-620	IC₅₀	30 μM Compound: 1	Cytotoxicity against human SW-620 cells and measured after 48 hrs by MTT assay Cytotoxicity against human SW-620 cells and measured after 48 hrs by MTT assay	[PMID: 35640100]

In Vitro

Anti-cancerBacterial Infection

Anti-cancer

Glenthmycin A (30 μM; 48 h) does not exhibit significant cytotoxicity against human colorectal carcinoma (SW620) or human lung carcinoma (NCI-H460) cells, with IC₅₀ > 30 μM^[1].

Bacterial Infection

Glenthmycin A (Compound 1) (0.01-30 μM; 16-24 h) inhibits the growth of S. aureus ATCC 25923 (IC₅₀ 6.4 μM), E. faecalis (IC₅₀ 5.7 μM), MRSA ATCC 43300 (IC₅₀ 4.4 μM), MRSA ATCC 33591 (IC₅₀ 1.9 μM), and VRE (IC₅₀ 5.2 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3040055-59-9
Molecular Weight 874.04
Formula C₄₉H₆₃NO₁₃
SMILES

OC=1[C@@]23[C@@](C=C(C(O)=O)[C@H](C)C2)(/C=C(\C)/CC/C=C(\C)/[C@]4([C@@](C)(C(=O)C1C(=O)O3)[C@]5([C@@]([C@@H](O[C@H]6[C@H](O)[C@](C)(O)[C@H](NC(=O)C7=C(C)C=C(OC)C=C7O)[C@@H](C)O6)CC[C@@H]5C)(C=C4C)[H])[H])[H])[H]
Structure Classification
- Others
Initial Source
- Microorganism
Streptomyces sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu T, et al. Glenthmycins A-M: Macrocyclic Spirotetronate Polyketide Antibacterials from the Australian Pasture Plant-Derived Streptomyces sp. CMB-PB041. J Nat Prod. 2022 Jun 24;85(6):1641-1657. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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