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Cat. No.: HY-114533

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GlmU-IN-1

GlmU-IN-1 is an inhibitor of the GlmU acetyltransferase domain in Escherichia coli and Haemophilus influenzae. GlmU-IN-1 acts as a competitive inhibitor of AcCoA and a non-competitive inhibitor of GlcN-1-P. GlmU-IN-1 targets the acetyltransferase domain of bacterial GlmU, interferes with the biosynthesis of UDP‑GlcNAc, and impairs bacterial cell wall integrity. GlmU-IN-1 can be used for the research of Gram-negative bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 104926-84-3
Formula: C₉H₇Cl₂N₃O
Molecular Weight:244.08

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Please store the product under the recommended conditions in the Certificate of Analysis.

GlmU-IN-1 Chemical Structure

CAS No.: 104926-84-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	>150 μg/mL	Cytotoxicity against human liver carcinoma HepG2 cells assessed via MTT assay after 24 h incubation. Cytotoxicity against human liver carcinoma HepG2 cells assessed via MTT assay after 24 h incubation.	26563552

In Vitro

OthersBacterial Infection

Others

GlmU-IN-1 (5175178) (0.39-100 μM; 30 min) potently and specifically inhibits the acetyltransferase activity of purified E. coli GlmU with an IC₅₀ of 1.40 μM, and inhibits the acetyltransferase activity of purified H. influenzae GlmU with an IC₅₀ of 79.92 μM. It acts as a competitive inhibitor against AcCoA and a non-competitive inhibitor against GlcN-1-P^[1].
GlmU-IN-1 (4 μg/mL; 30 min) disrupts the cell membrane permeability of E. coli ATCC 25922^[1].
GlmU-IN-1 (24 h) shows no cytotoxicity against HepG2 cells, with its CC₅₀ >150 μg/mL^[1].

Bacterial Infection

GlmU-IN-1 (0.0625-32 μg/mL; 24 h) exhibits bactericidal activity against E. coli ATCC 25922 (MIC 4 μg/mL, MBC 32 μg/mL), and also shows antibacterial activity against NDM1-producing A. baumanii and K. pneumoniae isolates^[1].
GlmU-IN-1 inhibits the growth of E. coli BL21 (DE3) by targeting GlmU. Compared with wild-type and empty vector control cells, the bacterial IC₅₀ of GlmU-overexpressing cells is four times higher^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Gram Staining of Tissue Sections

Chemical Information

CAS No. 104926-84-3
Molecular Weight 244.08
Formula C₉H₇Cl₂N₃O
SMILES

OC1=C2N=C(C=CC2=C(C=C1Cl)Cl)NN
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sharma R, et al. Identification and characterization of novel small molecule inhibitors of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Applied microbiology and biotechnology. 2016 Apr;100(7):3071-85.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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