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Cat. No.: HY-189112

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Globopentaosylceramide

Name: Globopentaosylceramide
Brand: MedChemExpress
SKU: HY-189112
Availability: PreOrder

(Synonyms: Gb5; Globoside Gb5; SSEA-3)

Globopentaosylceramide (Gb5) is a globo-series glycosphingolipid that is present in embryonic stem cells and embryonal carcinoma cells. Globopentaosylceramide is used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 171108-15-9
Formula: C₃₂H₅₅NO₂₆
Molecular Weight:869.77

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Please store the product under the recommended conditions in the Certificate of Analysis.

Globopentaosylceramide Chemical Structure

CAS No.: 171108-15-9

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Description

Globopentaosylceramide (Gb5) is a globo-series glycosphingolipid that is present in embryonic stem cells and embryonal carcinoma cells. Globopentaosylceramide is used in cancer-related research^[1]^[2]^[3]^[4]^[5]^[6].

In Vitro

Globopentaosylceramide/SSEA-3 is detected in both SA121 and SA181 human embryonic stem cell lines by the chromatogram binding assay^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 171108-15-9
Molecular Weight 869.77
Formula C₃₂H₅₅NO₂₆
SMILES

O([C@H]1[C@H](NC(C)=O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H](CO)O1)[C@@H]3[C@@H](O)[C@@H](O[C@H]4[C@@H](CO)O[C@@H](O[C@@H]5[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)O[C@H](CO)[C@@H]3O
Synonyms

Gb5; Globoside Gb5; SSEA-3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gupta V, et al. Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells. The Journal of biological chemistry. 2012 Oct 26;287(44):37195-205.

[2]. Häuselmann I, et al. Altered tumor-cell glycosylation promotes metastasis. Frontiers in oncology. 2014;4:28.

[3]. Handa K, et al. Changes of glycoconjugate expression profiles during early development. Glycoconjugate journal. 2017 Dec;34(6):693-699.

[4]. Cooling L, et al. A hemolytic anti-LKE associated with a rare LKE-negative, "weak P" red blood cell phenotype: alloanti-LKE and alloanti-P recognize galactosylgloboside and monosialogalactosylgloboside (LKE) antigens. Transfusion. 2015 Jan;55(1):115-28.

[5]. Barone A, et al. Structural complexity of non-acid glycosphingolipids in human embryonic stem cells grown under feeder-free conditions. The Journal of biological chemistry. 2013 Apr 05;288(14):10035-10050.

[6]. Masuda Y, et al. The effect of globopentaosylceramide on a depression model, mouse forced swimming. The Tohoku journal of experimental medicine. 2000 May;191(1):47-54.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Globopentaosylceramide

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