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Cat. No.: HY-187599

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Glutathione glycylethyl ester

Name: Glutathione glycylethyl ester
Brand: MedChemExpress
SKU: HY-187599
Availability: PreOrder

(Synonyms: GSH-[glycyl]ethyl ester; GSH(Et))

Glutathione glycylethyl ester (GSH-[glycyl]ethyl ester; GSH (Et)) is a cell-permeable glutathione derivative commonly used in experiments to increase or maintain intracellular GSH levels. Compared with unmodified glutathione, Glutathione glycylethyl ester is modified by glycyl esterification, enabling more efficient cellular entry and intracellular conversion to GSH.

For research use only. We do not sell to patients.

CAS No.: 145356-41-8
Formula: C₁₅H₂₅N₃O₈S
Molecular Weight:407.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Glutathione glycylethyl ester Chemical Structure

CAS No.: 145356-41-8

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Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Glutathione glycylethyl ester can be used as a biochemical detection reagent for experiments related to cellular redox, oxidative stress, antioxidation, and glutathione depletion. For example, the addition of Glutathione glycylethyl ester can be used to restore intracellular GSH levels and to study the effects of GSH-dependent effects on apoptosis and autophagy^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 145356-41-8
Molecular Weight 407.44
Formula C₁₅H₂₅N₃O₈S
SMILES

O=C(OCC)CNC(=O)C(NC(=O)CCC(N)C(=O)O)CSC(=O)C(O)C
Synonyms

GSH-[glycyl]ethyl ester; GSH(Et)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Horsley L, et al. A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours. Cancer chemotherapy and pharmacology. 2013 Dec;72(6):1343-52.

[2]. Levy EJ, et al. Transport of glutathione diethyl ester into human cells. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9171-5. [Content Brief]

[3]. Emery M, et al. Acute hypoglycemia induces retinal cell death in mouse. PLoS One. 2011;6(6):e21586.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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