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Cat. No.: HY-189101

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GPR109 receptor agonist-4

GPR109 receptor agonist-4 is a high-affinity GPR109a and low-affinity GPR109b niacin receptor agonist with EC₅₀ values of 24 μM and 4.8 μM, respectively. GPR109 receptor agonist-4 acts through Gi-coupled receptors to reduce intracellular cAMP, which in turn negatively regulates hormone-sensitive lipase activity and inhibits lipolysis. GPR109 receptor agonist-4 can be used in the study of atherosclerosis.

For research use only. We do not sell to patients.

CAS No.: 853260-98-7
Formula: C₁₃H₁₂O₄
Molecular Weight:232.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GPR109 receptor agonist-4 Chemical Structure

CAS No.: 853260-98-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

GPR109b

4.8 μM (EC₅₀)

In Vitro

GPR109 receptor agonist-4 (compound 5b) is a high-affinity GPR109a and low-affinity GPR109b niacin receptor agonist in the cAMP whole-cell assay, with EC₅₀ values of 24 μM and 4.8 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 853260-98-7
Molecular Weight 232.23
Formula C₁₃H₁₂O₄
SMILES

O=C(C(OC1(CC)C2=CC=CC=C2)=CC1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jung JK, et al. Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. Journal of medicinal chemistry. 2007 Apr 05;50(7):1445-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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