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Cat. No.: HY-W394903R

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GS-829845 (Standard)

GS-829845 (Standard) is the analytical standard of GS-829845 (HY-W394903). This product is intended for research and analytical applications. GS-829845 is a is a major, active metabolite of Filgotinib (HY-18300). GS-829845 is a JAK1 preferential inhibitor but is approximately 10-fold less potent than the parent and with a longer half-life.

For research use only. We do not sell to patients.

CAS No.: 1257705-09-1
Formula: C₁₇H₁₉N₅O₂S
Molecular Weight:357.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GS-829845 (Standard) Chemical Structure

CAS No.: 1257705-09-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1257705-09-1
Molecular Weight 357.43
Formula C₁₇H₁₉N₅O₂S
SMILES

O=S1(CCN(CC1)CC2=CC=C(C3=CC=CC4=NC(N)=NN43)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Meng A, et al. Exposure-response relationships for the efficacy and safety of filgotinib and its metabolite GS-829845 in subjects with rheumatoid arthritis based on phase 2 and phase 3 studies. Br J Clin Pharmacol. 2022;88(7):3211-3221. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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