country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-190204

Copy Link Print Information

GSPT1 degrader-21

GSPT1 degrader-21 (compound 12) is a cereblon (CRBN)-recruiting GSPT1 molecular glue degrader. GSPT1 degrader-21 promotes the ubiquitination and proteasomal degradation of GSPT1 and/or IKZF1. GSPT1 degrader-21 has a GSPT1 HiBiT DC₅₀ of < 1 nM. GSPT1 degrader-21 can be used for research on hematological tumors such as B-cell acute lymphoblastic leukemia and monocytic leukemia.

For research use only. We do not sell to patients.

CAS No.: 2930694-65-6
Formula: C₂₆H₂₃N₃O₄
Molecular Weight:441.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSPT1 degrader-21 Chemical Structure

CAS No.: 2930694-65-6

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Eukaryotic Release Factor (eRF) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MHH-CALL-4	EC50	< 1 nM	Exerts an anti-proliferative effect on MHH-CALL-4 (B-ALL) cells. Exerts an anti-proliferative effect on MHH-CALL-4 (B-ALL) cells.	en?oq=WO2023096822+A1
MV4-11	EC50	5 nM	Exerts an anti-proliferative effect on MV4-11 (B-ALL) cells. Exerts an anti-proliferative effect on MV4-11 (B-ALL) cells.	en?oq=WO2023096822+A1

In Vitro

Anti-cancerOthers

Anti-cancer

GSPT1 degrader-21 (72 h) has an EC₅₀ of < 0.001 μM for inhibiting MHH-CALL-4 (B-ALL) cell proliferation and an EC₅₀ of 0.005 μM for inhibiting MV4-11 cell proliferation^[1].

Others

GSPT1 degrader-21 (4 h) (compound 12) induces GSPT1 degradation in HEK293-hGSPT1-HiBiT cells with a HiBiT DC₅₀ of < 0.001 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2930694-65-6
Molecular Weight 441.48
Formula C₂₆H₂₃N₃O₄
SMILES

O=C(N1)CCC(N2CC3=C(C=CC(CC(NCC4=CC=CC5=CC=CC=C54)=O)=C3)C2=O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nishiguchi G A, et al. Substituted 2-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)acetamide analogs as modulators of gspt1 and/or ikzf1 protein. WO2023096822A1. WIPO. 2023‑06‑01.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

GSPT1 degrader-21

All Eukaryotic Release Factor (eRF) Isoforms