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Cat. No.: HY-190234

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GSPT1 degrader-25

GSPT1 degrader-25 is a degrader targeting GSGPT1 and inhibits KG-1 cell proliferation. GSPT1 degrader-25 can be used in leukemia-related research.

For research use only. We do not sell to patients.

CAS No.: 3053857-76-1
Formula: C₂₅H₂₂FN₃O₅
Molecular Weight:463.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSPT1 degrader-25 Chemical Structure

CAS No.: 3053857-76-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

GSPT1 degrader-25 is a degrader targeting GSGPT1 and inhibits KG-1 cell proliferation. GSPT1 degrader-25 can be used in leukemia-related research^[1].

IC₅₀ & Target

^[1]

eRF3a/GSPT1

All Eukaryotic Release Factor (eRF) Isoforms :

In Vitro

Anti-cancer

GSPT1 degrader-25 (A-31) (200 nM; 4 hours) induces GSGPT1 protein degradation in KG-1 cells, with a degradation rate ≥80%^[1].
GSPT1 degrader-25 inhibits KG-1 leukemia cell proliferation, with 1 nM ≤ IC₅₀ < 10 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3053857-76-1
Molecular Weight 463.46
Formula C₂₅H₂₂FN₃O₅
SMILES

O=C(C(CO1)=CC2=C1C(C)=CC(F)=C2)NCC3=CC4=C(C(N(C(CC5)C(NC5=O)=O)C4)=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li Z, et al. Benzo-six-membered heterocyclic GSPT protein degradation agent and application thereof. CN118496213A, 2024.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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