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Cat. No.: HY-P12327

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H-Hyp-Leu-OH

H-Hyp-Leu-OH is a linear dipeptide of hydroxyproline-leucine with anti-inflammatory and antioxidant activities. H-Hyp-Leu-OH inhibits NO, IL-1β, IL-6, and TNF-α in macrophages, and upregulates IL-10. H-Hyp-Leu-OH extends lifespan, improves exercise capacity, reduces ROS and MDA, and increases SOD, CAT, and GSH-Px. H-Hyp-Leu-OH can be used for epithelial ovarian cancer and antioxidant-related research.

For research use only. We do not sell to patients.

CAS No.: 637030-43-4
Formula: C₁₁H₂₀N₂O₄
Molecular Weight:244.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

H-Hyp-Leu-OH Chemical Structure

CAS No.: 637030-43-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

IL-6

IL-1β

IL-10

TNF-α

All Interleukin Related Isoforms :

All NO Synthase Isoforms :

All TNF Receptor Isoforms :

In Vitro

Oxidative StressOthers

Oxidative Stress

H-Hyp-Leu-OH (Leu-Hyp) (1.0 mg/mL; 30 min) exhibits free radical scavenging activity against DPPH• and ABTS•⁺^[1].
H-Hyp-Leu-OH (0.1 mg/mL; 24 h) exhibits no cytotoxicity and exerts anti-inflammatory effects in RAW264.7 macrophages by inhibiting pro-inflammatory mediators (IL-1β, IL-6, and TNF-α) and upregulating IL-10^[1].

Others

H-Hyp-Leu-OH (Hyp-Leu) can serve as a marker to distinguish epithelial ovarian cancer from benign ovarian tumors^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

RAW264.7 murine macrophage cells
Concentration:

0.1 mg/mL
Incubation Time:

24 h
Result:

Showed no significant cytotoxicity.

In Vivo

Oxidative Stress

H-Hyp-Leu-OH (Leu-Hyp) (1 mg/mL) enhances the endogenous antioxidant defense of C. elegans by increasing SOD, CAT, and GSH-Px activities, extends the lifespan of Caenorhabditis elegans by enhancing endogenous antioxidant defense capacity, and improves locomotor ability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 637030-43-4
Molecular Weight 244.29
Formula C₁₁H₂₀N₂O₄
Sequence

Hyp-Leu
Sequence Shortening

{Hyp}-L
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu L, et al. Structural basis for the anti-aging effects of hydroxyproline-BCAA dipeptides: An integrated computational and experimental approach. Food research international (Ottawa, Ont.). 2026 Jan 31;224:117962.

[2]. Lu X, et al. Selection of small plasma peptides for the auxiliary diagnosis and prognosis of epithelial ovarian cancer by using UPLC/MS-based nontargeted and targeted analyses. International Journal of Cancer, 2019, 144(8): 2033-2042.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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H-Hyp-Leu-OH

All Interleukin Related Isoforms

All NO Synthase Isoforms

All TNF Receptor Isoforms