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Cat. No.: HY-P12367

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H-Phe-Ser-Ala-OH

H-Phe-Ser-Ala-OH is a tripeptide and hPEPT1 ligand with a K_i value of 0.3 μM at hPEPT1 (Caco-2 cells). H-Phe-Ser-Ala-OH serves as a lead moiety for the design of hPEPT1-targeting compounds.

For research use only. We do not sell to patients.

CAS No.: 847780-73-8
Formula: C₁₅H₂₁N₃O₅
Molecular Weight:323.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

H-Phe-Ser-Ala-OH Chemical Structure

CAS No.: 847780-73-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

H-Phe-Ser-Ala-OH is a tripeptide and hPEPT1 ligand with a K_i value of 0.3 μM at hPEPT1 (Caco-2 cells). H-Phe-Ser-Ala-OH serves as a lead moiety for the design of hPEPT1-targeting compounds^[1]^[2].

In Vitro

H-Phe-Ser-Ala-OH is a high-affinity substrate of hPEPT1 in Caco-2 cell monolayers, with a K_i of 0.30 μM^[1].
H-Phe-Ser-Ala-OH is efficiently transported by hPEPT1, whereas certain N-terminal modifications abolish this transport^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 847780-73-8
Molecular Weight 323.34
Formula C₁₅H₂₁N₃O₅
Sequence

Phe-Ser-Ala
Sequence Shortening

FSA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Thorn K, et al. Design, synthesis, and evaluation of tripeptidic promoieties targeting the intestinal peptide transporter hPEPT1. ChemMedChem. 2007 Apr;2(4):479-87.

[2]. Omkvist DH, et al. Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2011 Feb;77(2):327-31. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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