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Cat. No.: HY-W162231

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HC102A

HC102A is an Antibacterial agent and an inhibitor of DosS and DosT histidine sensor kinases, with an IC₅₀ of 1.9 μM against Mycobacterium tuberculosis DosS. HC102A does not alter the heme redox state of sensor kinases. HC102A reduces triacylglycerol synthesis and accumulation, decreases the survival rate of Mtb under non-replicating persistent and hypoxic conditions, and enhances the sensitivity of Mtb to Isoniazid (HY-B0329). HC102A can be used in research related to tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 91216-38-5
Formula: C₁₁H₁₈N₂O₂
Molecular Weight:210.28

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Please store the product under the recommended conditions in the Certificate of Analysis.

HC102A Chemical Structure

CAS No.: 91216-38-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

In Vitro

Bacterial InfectionLipid MetabolismOthers

Bacterial Infection

HC102A (0.01-100 μM) potently and selectively inhibits DosR-dependent GFP fluorescence in Mtb CDC1551 (hspX′::GFP), with an EC₅₀ of 12.4 μM^[1].

Bacterial Infection

Lipid Metabolism

HC102A (40 μM; 6 days) reduces TAG accumulation by 67% in Mtb CDC1551, thereby disrupting a key lipid metabolic process associated with persistence^[1].

Bacterial Infection

HC102A (1-100 μM; 10 days) reduces the survival rates of Mtb CDC1551 and Erdman strains in a dose-dependent manner under hypoxic NRP conditions, and decreases the strain survival rate by approximately 50% at a dose of 10 μM^[1].

Bacterial Infection

HC102A (1 h) directly inhibits autophosphorylation of purified Mtb DosS protein with an IC₅₀ of 1.9 μM, but has minimal effect on autophosphorylation of DosT^[1].

Others

HC102A directly inhibits the autophosphorylation activity of the Mycobacterium tuberculosis DosS sensor kinase, but exerts no such effect on the DosT sensor kinase^[2].

Bacterial Infection

HC102A inhibits the autokinase activity of DosS and DosT histidine kinases in *Mycobacterium tuberculosis*, reduces the hypoxia-induced survival rate of *Mycobacterium tuberculosis*, and exhibits extremely low cytotoxicity against mammalian cell lines^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 91216-38-5
Molecular Weight 210.28
Formula C₁₁H₁₈N₂O₂
SMILES

O=C1NC(=O)C2(N1)CC(C)CC(C)(C)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zheng H, et al. Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nature chemical biology. 2017 Feb;13(2):218-225. [Content Brief]

[2]. Johnson BK, et al. Small Molecules That Sabotage Bacterial Virulence. Trends in pharmacological sciences. 2017 Apr;38(4):339-362. [Content Brief]

[3]. Stupar M, et al. Two-component sensor histidine kinases of Mycobacterium tuberculosis: Beacons for niche navigation. Molecular microbiology. 2022 May;117(5):973-985. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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HC102A

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

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HC102A Related Classifications

HY-W162231 Related Classifications

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