HDAC6-IN-85
Based on 1 Customer Validation
HDAC6-IN-85 is a selective HDAC6 inhibitor, with pIC50 values of 5.4, 5.5, 5.9, and 4.8 against rHDAC1, rHDAC3, rHDAC6, and rHDAC8, respectively. HDAC6-IN-85 can be used in the research of cervical cancer, lung cancer, and colon cancer.
For research use only. We do not sell to patients.
- Purity : 97.58%
- CAS No.: 948837-73-8
- Formula: C12H14O2S3
- Molecular Weight:286.43
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HDAC1 5.4 (pIC50) |
HDAC3 5.5 (pIC50) |
HDAC6 5.9 (pIC50) |
HDAC8 4.8 (pIC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
4.56 μM
Compound: 3a
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Inhibition of recombinant HDAC1 expressed in HEK293 cells
Inhibition of recombinant HDAC1 expressed in HEK293 cells
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[PMID: 18558669] |
| HEK293 | IC50 |
1.22 μM
Compound: 3a
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Inhibition of recombinant HDAC6 expressed in HEK293 cells
Inhibition of recombinant HDAC6 expressed in HEK293 cells
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[PMID: 18558669] |
| HeLa | IC50 |
0.375 μM
Compound: 3a
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Inhibition of nuclear HDAC isolated from human HeLa cells
Inhibition of nuclear HDAC isolated from human HeLa cells
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[PMID: 18558669] |
| HeLa | IC50 |
4.67 μM
Compound: 3a
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Inhibition of HDAC in human HeLa cells
Inhibition of HDAC in human HeLa cells
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[PMID: 18558669] |
| HeLa | IC50 |
1.96 μM
Compound: 3a
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Cytotoxicity against human HeLa cells after 72 hrs by alamar blue assay
Cytotoxicity against human HeLa cells after 72 hrs by alamar blue assay
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[PMID: 18558669] |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 948837-73-8
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Appearance Solid
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Molecular Weight 286.43
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Formula C12H14O2S3
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Color Light yellow to yellow
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SMILES
O=C(CSC(SCC)=S)C1=CC=C(C=C1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (349.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4913 mL | 17.4563 mL | 34.9125 mL | 87.2814 mL |
| 5 mM | 0.6983 mL | 3.4913 mL | 6.9825 mL | 17.4563 mL | |
| 10 mM | 0.3491 mL | 1.7456 mL | 3.4913 mL | 8.7281 mL | |
| 15 mM | 0.2328 mL | 1.1638 mL | 2.3275 mL | 5.8188 mL | |
| 20 mM | 0.1746 mL | 0.8728 mL | 1.7456 mL | 4.3641 mL | |
| 25 mM | 0.1397 mL | 0.6983 mL | 1.3965 mL | 3.4913 mL | |
| 30 mM | 0.1164 mL | 0.5819 mL | 1.1638 mL | 2.9094 mL | |
| 40 mM | 0.0873 mL | 0.4364 mL | 0.8728 mL | 2.1820 mL | |
| 50 mM | 0.0698 mL | 0.3491 mL | 0.6983 mL | 1.7456 mL | |
| 60 mM | 0.0582 mL | 0.2909 mL | 0.5819 mL | 1.4547 mL | |
| 80 mM | 0.0436 mL | 0.2182 mL | 0.4364 mL | 1.0910 mL | |
| 100 mM | 0.0349 mL | 0.1746 mL | 0.3491 mL | 0.8728 mL |
HDAC6-IN-85 Related Classifications
HY-184525 Related Classifications
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