country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-187210

Copy Link Print Information

HDAC6-IN-86

HDAC6-IN-86 is a histone deacetylase 6 (HDAC6) inhibitor with an IC₅₀ of 74 nM, and it exhibits high selectivity for HDAC1. HDAC6-IN-86 induces cell apoptosis, triggers G₂/M phase cell cycle arrest, and inhibits the proliferation of glioma cells. HDAC6-IN-86 can be used for the research of glioblastoma multiforme (GBM).

For research use only. We do not sell to patients.

CAS No.: 2271229-98-0
Formula: C₂₁H₁₈N₂O₃S
Molecular Weight:378.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC6-IN-86 Chemical Structure

CAS No.: 2271229-98-0

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

HDAC6

74 nM (IC₅₀)

All HDAC Isoforms :

In Vitro

Anti-cancerApoptosisCell Cycle Regulation

Anti-cancer

HDAC6-IN-86 (Compound 6d) potently inhibits the proliferation of U87MG and U118MG glioblastoma cells, with IC₅₀ values of 2.65 μM and 2.79 μM, respectively, while exhibiting low toxicity against normal LO2 hepatocytes (IC₅₀ = 32.64 μM)^[1].

Apoptosis

Anti-cancer

HDAC6-IN-86 (1-27 μM; 24 h) induces dose-dependent apoptosis in U87MG glioblastoma cells^[1].

Cell Cycle Regulation

Anti-cancer

HDAC6-IN-86 (1-27 μM; 24 h) induces dose-dependent G2/M cell cycle arrest in U87MG glioblastoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

human glioblastoma U87MG cells
Concentration:

1, 3, 9 and 27 μM
Incubation Time:

24 h
Result:

Induced dose-dependent apoptosis in U87MG cells with total apoptotic rate of 7.78% at 1 μM.
Induced total apoptotic rate of 11.51% at 3 μM.
Induced total apoptotic rate of 17.49% at 9 μM.
Induced total apoptotic rate of 32.02% at 27 μM.

Cell Cycle Analysis^[1]

Cell Line:

human glioblastoma U87MG cells
Concentration:

1, 3, 9 and 27 μM
Incubation Time:

24 h
Result:

Induced dose-dependent G2/M phase cell cycle arrest in U87MG cells.
Arrested over 70% of cells in G2/M phase at 27 μM, with a corresponding decrease in the proportion of cells in G0/G1 phase.

Related Protocols :

Chemical Information

CAS No. 2271229-98-0
Molecular Weight 378.44
Formula C₂₁H₁₈N₂O₃S
SMILES

O=C(NO)C(C=C1)=CC=C1CN2C3=CC=CC=C3SC4=C2C=C(OC)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu Y, et al. Synthesis and biological investigation of phenothiazine-based derivatives as potential HDAC6 inhibitors for treatment of glioblastoma multiforme. Bioorganic & medicinal chemistry letters. 2026 Jul 06;140:130729. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

HDAC6-IN-86

All HDAC Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HDAC6-IN-86 Related Classifications

HY-187210 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target