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Cat. No.: HY-187045

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Heliantriol C

Heliantriol C is a taraxerane-type trihydroxy triterpenoid present in the ray florets of Asteraceae plants. Heliantriol C inhibits TPA (HY-18739)-induced inflammation. Heliantriol C exhibits anticancer activity, and its acetylated derivatives show enhanced cytotoxicity against cancer cells. Heliantriol C can be used in studies related to inflammation and cancers such as leukemia and lung cancer.

For research use only. We do not sell to patients.

CAS No.: 71876-60-3
Formula: C₃₀H₅₀O₃
Molecular Weight:458.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Heliantriol C Chemical Structure

CAS No.: 71876-60-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
- In Vivo
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Biological Activity

Description

In Vitro

Anti-cancerOthers

Anti-cancer

Heliantriol C (compound 3) (48 h) exhibits lower cytotoxicity against the human cancer cell lines HL60, A549, AZ521 and SK-BR-3 than dihydroxy taraxastane-type triterpenoids and their acetyl derivatives^[2].

Others

Heliantriol C undergoes acetylation with Ac₂O in pyridine to form heliantriol C 3,16,22-tri-O-acetate (compound 25); oxidation with MnO₂ in CHCl₃ yields 22-oxofaradiol (compound 26)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

OthersAnti-cancer

Others

Heliantriol C (compound 3) (0.03 mg/ear; local administration; single dose) potently inhibits TPA (HY-18739)-induced ear swelling in female ICR mice, with an ID₅₀ of 0.03 mg/ear^[1].

Anti-cancer

Heliantriol C (0.2 μmol per mouse; topical administration; administered 30 minutes before each TPA treatment, twice weekly, for 20 weeks) reduces the average number of skin tumors per mouse and decreases the proportion of tumor-bearing mice at week 20 in the DMBA/TPA two-stage mouse skin carcinogenesis model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice (female, 7 weeks old, two-stage skin tumorigenesis model initiated by DMBA, promoted by TPA)^[3]
Dosage:

0.2 μmol per mouse
Administration:

topical; 30 minutes before each twice-weekly TPA application; 20 weeks
Result:

Delayed initial skin tumor onset until week 13 (control: week 8).
Lowered tumor-bearing mouse ratio to 20% at week 20 (control: 93%).
Cut average tumor count per mouse to 0.9 at week 20 (control: 8.6).
Produced obvious disparities versus control starting at week 11.
Generated distinct differences versus faradiol group from week 16 to 20.

Related Protocols :

Chemical Information

CAS No. 71876-60-3
Molecular Weight 458.73
Formula C₃₀H₅₀O₃
SMILES

C[C@]12[C@@]([C@@]3([C@@](C)([C@@H](O)C1)[C@@H](O)C=C(C)[C@H]3C)[H])(CC[C@]4([C@@]2(C)CC[C@@]5([C@]4(C)CC[C@H](O)C5(C)C)[H])[H])[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yasukawa K, et al. Inhibitory effect of Di- and trihydroxy triterpenes from the flowers of compositae on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. Biological & pharmaceutical bulletin. 1996 Oct;19(10):1329-31. [Content Brief]

[2]. Ukiya M, et al. Cytotoxic and Apoptosis‑inducing Activities of Taraxastane‑type Triterpenoid Derivatives in Human Cancer Cell Lines. Chemistry & Biodiversity, 2016, 13(8): 1018‑1029.

[3]. Yasukawa K, et al. Inhibitory effect of heliantriol C; a component of edible Chrysanthemum, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Phytomedicine : international journal of phytotherapy and phytopharmacology. 1998 May;5(3):215-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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