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Cat. No.: HY-N20749

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Hericene C

Hericene C is a geranyl resorcinol metabolite. Hericene C exerts a protective effect against Thapsigargin-induced endoplasmic reticulum stress-dependent cell death. Hericene C can be used for research on neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 157207-56-2
Formula: C₃₇H₆₀O₅
Molecular Weight:584.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hericene C Chemical Structure

CAS No.: 157207-56-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Endoplasmic Reticulum Stress

Hericene C (2c) (0-100; 24 h) exhibits moderate protective activity against Thapsigargin (HY-13433)-induced ER stress-dependent cell death in Neuro2a cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

Neuro2a
Concentration:

0, 10, 30, 100 μM
Incubation Time:

24 h
Result:

Exhibited moderate protective activity against TG-induced ER stress at concentrations above 30 μM.
Showed no significant protection against TM-induced ER stress.
Regioisomers 7b and 7c increased cell viability by approximately 20% at 10 μM in TM-induced ER stressed cells.

Related Protocols :

Chemical Information

CAS No. 157207-56-2
Molecular Weight 584.87
Formula C₃₇H₆₀O₅
SMILES

CCCCCCCCCCCCCCCCCC(OCC1=C(C=O)C(O)=C(C/C=C(CC/C=C(C)/C)\C)C(OC)=C1)=O
Structure Classification
- Others
Initial Source
- Microorganisms
Hericium erinaceum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Corana F, et al. Array of Metabolites in Italian Hericium erinaceus Mycelium, Primordium, and Sporophore. Molecules. 2019 Sep 27;24(19):3511.

[2]. Kobayashi S, et al. Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A− C and their derivatives. Tetrahedron Letters. 2018 May 2;59(18):1733-6.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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