Hericerin A
Hericerin A is an isoindolinone derivative and a selective cytotoxic agent. Hericerin A is isolated from Hericium erinaceus cultured on brown rice. Hericerin A downregulates the phosphorylation of AKT and downregulates c-Myc oncoprotein levels downstream of p-AKT inactivation. Hericerin A induces Apoptosis. Hericerin A exhibits anticancer activity against leukemia. Hericerin A is used in research on acute promyelocytic leukemia, breast cancer, and Helicobacter pylori infection.
For research use only. We do not sell to patients.
- CAS No.: 1629208-29-2
- Formula: C21H29NO4
- Molecular Weight:359.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Description
IC50 & Target
[1]|
Fungal Metabolite |
In Vitro
Hericerin A (0.01-100 μM; 72 h) exhibits weak cytotoxicity against HEL-299 cells, inhibiting growth by less than 30% at concentrations up to 50 μM, with an IC50 of 64.61 μM[1].
Hericerin A inhibits proliferation and induces apoptosis in HL-60 leukemia cells with an IC50 of 3.06 μmol/L and in HEL-299 cells with an IC50 of 64.61 μmol/L[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL-60 human acute promyelocytic leukaemia cells
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Concentration:0.01-100 μM
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Incubation Time:72 h
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Result:Reduced the percentage of viable HL-60 cells with an IC50 value of 3.06 μM.
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Cell Line:HEL-299 human lung fibroblast cells
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Concentration:0.01-100 μM
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Incubation Time:72 h
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Result:Inhibited the growth of HEL-299 cells by less than 30% at concentrations up to 50 μM with an IC50 value of 64.61 μM.
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Cell Line:HL-60 cells
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Concentration:3.06 μM
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Incubation Time:24 h; 48 h
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Result:Increased the proportion of sub-G1 fraction (M1) cells to 10.30% at 24 h and 13.49% at 48 h.\nIncreased the number of apoptotic bodies after 24 and 48 h incubation periods.
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Cell Line:HL-60 cells
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Concentration:3.06 μM
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Incubation Time:24 h; 48 h
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Result:Increased Bax expression and decreased Bcl-2 expression in a time-dependent manner.
Increased active forms of caspase-3 and caused proteolytic cleavage of PARP.
Decreased p-AKT levels and down-regulated c-myc.
- Kinase activity and phosphorylation assays
- Western Blot
- Research Protocol for Infectious Diseases
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Annexin V plus membrane-impermeant dye apoptosis staining
- Apoptosis Solutions
- Protocol for Kinase activity and phosphorylation assays
- Breast Cancer Modeling
- Cell Viability Determination by MTT Colorimetric Assay
Chemical Information
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CAS No. 1629208-29-2
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Molecular Weight 359.47
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Formula C21H29NO4
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SMILES
OC1=C2C(=CC(OC)=C1C/C=C(/CCC=C(C)C)\C)C(=O)N(CCO)C2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hericerin A Related Classifications
HY-N21648 Related Classifications
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