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Cat. No.: HY-187362

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HIV-1 ligand-1

HIV-1 ligand-1 (IIA-5) is a PROTAC target protein ligand. HIV-1 ligand-1 can be used for the synthesis of PROTAC HIV-1 degrader-1 (HY-187361).

For research use only. We do not sell to patients.

CAS No.: 3107740-50-8
Formula: C₂₇H₂₁ClF₃N₃O₄
Molecular Weight:543.92

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HIV-1 ligand-1 Chemical Structure

CAS No.: 3107740-50-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

HIV-1 ligand-1 (IIA-5) is a PROTAC target protein ligand. HIV-1 ligand-1 can be used for the synthesis of PROTAC HIV-1 degrader-1 (HY-187361)^[1].

IC₅₀ & Target

^[1]

HIV-1_IIIB

HIV-1 NL4-3

All HIV Isoforms :

In Vitro

Binding of the ligand to the target protein causes the PROTAC to attach to the target protein, leading to ubiquitination and subsequent degradation.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3107740-50-8
Molecular Weight 543.92
Formula C₂₇H₂₁ClF₃N₃O₄
SMILES

O=C(O)C1=CC(N(C)C([C@@H](NC(CC2=CNC3=C2C=C(F)C=C3)=O)CC4=CC(F)=CC(F)=C4)=O)=CC=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang M, et al. Targeted Degradation of Capsid by Host-Hijacking PROTAC Overcomes Drug Resistance. Journal of medicinal chemistry. 2026 Jul 23;69(14):16878-16895. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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HIV-1 ligand-1

All HIV Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HIV-1 ligand-1 Related Classifications

HY-187362 Related Classifications

Bioz

Keywords

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