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Cat. No.: HY-P12338

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HNSS peptide

HNSS peptide is a chimeric hybrid peptide composed of the neuroprotective peptide S14G-Humanin and the mitochondria-targeted antioxidant peptide SS31. HNSS peptide is readily cleared in vivo and can be combined with nanocarriers to improve its stability. HNSS can be delivered via the FGFR1-targeting nanocarrier FGL-NP (Cit), ameliorating mitochondrial dysfunction, Aβ deposition, tau hyperphosphorylation, and cholinergic neuronal damage, and alleviating memory deficits in Alzheimer's disease mice. HNSS peptide is applicable for Alzheimer's disease-related research.

For research use only. We do not sell to patients.

Formula: C₁₅₄H₂₅₅N₄₅O₃₇S₂
Molecular Weight:3393.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HNSS peptide Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

p-STAT3

All STAT Isoforms :

In Vitro

OthersMitochondrial FunctionAβ/Tau/α-Synuclein AggregationOxidative Stress

Others

HNSS peptide is efficiently encapsulated into NP (Cit) nanoparticles via electrostatic interactions, with high encapsulation efficiency and drug loading capacity; after encapsulation, its stability in plasma and brain homogenate is significantly enhanced, and it exhibits pH-responsive drug release characteristics, with accelerated HNSS release under acidic pH 5.0 conditions^[1].

Mitochondrial Function

Aβ/Tau/α-Synuclein Aggregation

HNSS peptide (10 μM) most effectively inhibits H₂O₂-induced intracellular and mitochondrial ROS production in HT22 cells^[1].

Oxidative Stress

Mitochondrial Function

HNSS peptide (10 μM; 24 h) most effectively restores mitochondrial function in Aβ_25-35 (HY-P0128)-treated HT22 cells by upregulating p-STAT3, MTCO1, and MnSOD, and by improving mitochondrial membrane potential, ATP levels, and cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HT22 cells
Concentration:

25 μM Aβ_25-35 (HY-P0128)10 μM HNSS preparations
Incubation Time:

24 h
Result:

Strongly upregulated the expression of p-STAT3, MTCO1, and MnSOD.

In Vivo

HNSS peptide encapsulated in FGL-NP (Cit) (intravenous injection of FGL-NP (Cit)/HNSS; 0.3 mg/kg/d; 4 h-4 weeks) achieves brain enrichment levels 4.8 times higher than the free form; it penetrates the blood-brain barrier via FGFR1-mediated transcytosis, targets cholinergic neurons in the lesioned brain regions of mice, achieves lysosomal escape through pH-triggered charge reversal, and accumulates in neuronal mitochondria under the guidance of SS31; it inhibits Aβ deposition and tau hyperphosphorylation in the brain, ameliorates cholinergic neuronal damage, elevates hippocampal acetylcholine levels, and alleviates spatial memory deficits, with no significant systemic toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 3393.08
Formula C₁₅₄H₂₅₅N₄₅O₃₇S₂
SMILES

O=C([C@H](N)CCCNC(N)=N)N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)C(C)C)=O)CCC2)=O)CC(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CS)=O)CO)=O)CC3=CC=CC=C3)=O)=O)CCCNC(N)=N)=O)CCC1)=O)C)=O)CCSC)=O)=O)=O)CC4=CC=CC=C4)=O)CCCCN)=O)CC5=C(C=C(O)C=C5C)C
Sequence

DArg-Tyr(2,6-diMe)-Lys-Phe-Gly-Gly-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-NH2
Sequence Shortening

DArg-Tyr(2,6-diMe)-KFGGMAPRGFSCLLLLTGEIDLPVKRRA-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Qian K, et al. Cholinergic Neuron Targeting Nanosystem Delivering Hybrid Peptide for Combinatorial Mitochondrial Therapy in Alzheimer's Disease. ACS nano. 2022 Jul 26;16(7):11455-11472.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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HNSS peptide

All STAT Isoforms