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Cat. No.: HY-189015

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Homo-AMPA

Homo-AMPA is a stereospecific mGluR6 agonist (EC₅₀ = 58 μM) and a weak NMDA (HY-17551) receptor antagonist (IC₅₀ = 131 μM), exerting anxiolytic-like effects and modulating pain-responsive neuronal activity through selective activation of mGluR6. Homo-AMPA can serve as a standard agonist for the pharmacological characterization of mGluR6 in related studies.

For research use only. We do not sell to patients.

CAS No.: 179169-88-1
Formula: C₈H₁₂N₂O₄
Molecular Weight:200.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Homo-AMPA Chemical Structure

CAS No.: 179169-88-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[2]

mGluR6

58 μM (EC₅₀)

All mGluR Isoforms :

In Vitro

Glutamate Release or Receptors

Homo-AMPA is a potent mGluR agonist that specifically activates mGluR6^[2].
Homo-AMPA (1000 μM; 100 μM) lacks detectable agonist activity in rat cortical slice preparations (EC₅₀ > 1000 μM) and shows no antagonist activity at 100 μM^[5].
Homo-AMPA (1-300 μM) does not alter extracellular glutamate levels in the nucleus accumbens of adult rats^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Glutamate Release or ReceptorsOthers

Glutamate Release or Receptors

Homo-AMPA (250 nmol/rat; local intrahippocampal administration) produces anxiolytic-like effects in rats, indicating that mGluR6 is involved in the anxiolytic-like effects of group III mGluR agonists in the hippocampus^[1].

Others

Homo-AMPA (microinjected into the ventrolateral midbrain periaqueductal gray (vl-PAG)) modulates RVM ON and OFF cell activity in a manner consistent with the pain-inhibitory effect of mGluR6 within the PAG^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats^[1]
Dosage:

250 nmol/rat
Administration:

local administration into the hippocampus
Result:

Produced an anxiolytic-like effect at 250 nmol/rat.
Reversed by (RS)-α-cyclopropyl-4-phosphonophenylglycine (CPPG).

Related Protocols :

Neuronal voltage-sensitive dye imaging

Chemical Information

CAS No. 179169-88-1
Molecular Weight 200.19
Formula C₈H₁₂N₂O₄
SMILES

O=C1NOC(C)=C1CCC(C(O)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Palazzo E, et al. The Cold Case of Metabotropic Glutamate Receptor 6: Unjust Detention in the Retina?. Current neuropharmacology. 2020;18(2):120-125.

[2]. P Krogsgaard-Larsen, et al. Design of excitatory amino acid receptor agonists, partial agonists and antagonists: ibotenic acid as a key lead structure, European Journal of Medicinal Chemistry, Volume 31, Issues 7–8, 1996, Pages 515-537, ISSN 0223-5234.

[3]. Selective Agonists at Group II Metabotropic Glutamate Receptors: Synthesis, Stereochemistry, and Molecular Pharmacology of (S)- and (R)-2-Amino-4-(4-hydroxy[1 …

[4]. Greenwood JR, et al. 3-hydroxypyridazine 1-oxides as carboxylate bioisosteres: a new series of subtype-selective AMPA receptor agonists. Neuropharmacology. 2006 Jul;51(1):52-9.

[5]. U Madsen, et al. Design, synthesis and pharmacology of model compounds for indirect elucidation of the topography of AMPA receptor sites, European Journal of Medicinal Chemistry,
Volume 28, Issue 10, 1993, Pages 791-800, ISSN 0223-5234.

[6]. Xi ZX, et al. Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens. Journal of neurochemistry. 2003 Dec;87(5):1204-12.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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