HTS10307
Based on 1 Customer Validation
HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease.
For research use only. We do not sell to patients.
- Purity : 99.29%
- CAS No.: 81682-91-9
- Formula: C14H8N2O2S
- Molecular Weight:268.29
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All AP-1 Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
FosB |
Chemical Information
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CAS No. 81682-91-9
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Appearance Solid
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Molecular Weight 268.29
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Formula C14H8N2O2S
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Color Light brown to yellow
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SMILES
O=C(N1)C(C#N)=C(C2=CC=CO2)C=C1C3=CC=CS3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (372.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7273 mL | 18.6365 mL | 37.2731 mL | 93.1827 mL |
| 5 mM | 0.7455 mL | 3.7273 mL | 7.4546 mL | 18.6365 mL | |
| 10 mM | 0.3727 mL | 1.8637 mL | 3.7273 mL | 9.3183 mL | |
| 15 mM | 0.2485 mL | 1.2424 mL | 2.4849 mL | 6.2122 mL | |
| 20 mM | 0.1864 mL | 0.9318 mL | 1.8637 mL | 4.6591 mL | |
| 25 mM | 0.1491 mL | 0.7455 mL | 1.4909 mL | 3.7273 mL | |
| 30 mM | 0.1242 mL | 0.6212 mL | 1.2424 mL | 3.1061 mL | |
| 40 mM | 0.0932 mL | 0.4659 mL | 0.9318 mL | 2.3296 mL | |
| 50 mM | 0.0745 mL | 0.3727 mL | 0.7455 mL | 1.8637 mL | |
| 60 mM | 0.0621 mL | 0.3106 mL | 0.6212 mL | 1.5530 mL | |
| 80 mM | 0.0466 mL | 0.2330 mL | 0.4659 mL | 1.1648 mL | |
| 100 mM | 0.0373 mL | 0.1864 mL | 0.3727 mL | 0.9318 mL |
HTS10307 Related Classifications
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