IDH1/2-IN-1
IDH1/2-IN-1 (Compound 6b) serves as a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. IDH1/2-IN-1 effectively inhibits tumor growth by suppressing tumor cell proliferation and enhancing host defense through the activation of antioxidant enzymes. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating robust antitumor activity. IDH1/2-IN-1 holds potential for research in leukemia.
For research use only. We do not sell to patients.
- Formula: C26H28N8O6S
- Molecular Weight:580.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 0.22 μM (IDH1(R132H))[1].
IC50: 1.6 μM (IDH2(R140Q))[1].
In Vitro
IDH1/2-IN-1 (Compound 6b) exhibits superior antitumor activity against THP1 and Kasumi leukemia cancer cells with IC50 values of 10.7 μM and 10 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Patient-Derived Orthotopic Xenograft (PDOX)
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Research Protocol for Inflammation-related Diseases
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Patient-Derived Xenograft (PDX)
- Apoptosis Solutions
- Subcutaneous Cell-Line-Derived Xenograft
- MTT Cell Proliferation Assay
- Orthotopic Cell-Line Xenograft
Chemical Information
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Molecular Weight 580.62
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Formula C26H28N8O6S
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SMILES
O=S(C1=CC=C(NC2=NC(NC3=CC=C(OC)C=C3)=NC(N/N=C/C4=CC(OC)=C(OC)C(OC)=C4)=N2)C=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IDH1/2-IN-1 Related Classifications
HY-162772 Related Classifications
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