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Cat. No.: HY-190208

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IKZF2 degrader-10

IKZF2 degrader-10 is a selective IKZF2 Molecular glue degrader. IKZF2 degrader-10 promotes IKZF2 ubiquitination and degradation. IKZF2 degrader-10 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 2988100-62-3
Formula: C₂₇H₃₅N₃O₃
Molecular Weight:449.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IKZF2 degrader-10 Chemical Structure

CAS No.: 2988100-62-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

IKZF2 degrader-10 is a selective IKZF2 Molecular glue degrader. IKZF2 degrader-10 promotes IKZF2 ubiquitination and degradation. IKZF2 degrader-10 can be used in cancer research^[1].

IC₅₀ & Target

^[1]

IZKF2

0.005 μM (EC₅₀)

IKZF1

0.574 μM (EC₅₀)

All IKZF Family Isoforms :

In Vitro

IKZF2 degrader-10 (Compound 29) (18-24 h) selectively degrades IKZF2 in HEK293 cells with an EC₅₀ of 0.005 μM and an EC₅₀ of 0.574 μM for IKZF1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2988100-62-3
Molecular Weight 449.59
Formula C₂₇H₃₅N₃O₃
SMILES

O=C(N(C1CCC(NC1=O)=O)C2)C(C=C3)=C2C=C3C[C@@H]4[C@@H](NC5CC6CC(C5)C6)CCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gayatri BALAN, et al. Ikaros zinc finger family degraders and uses thereof. WO2023178181A1. WIPO (PCT). 2023-03-15.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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