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Cat. No.: HY-190242

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IKZF2 degrader-7

IKZF2 degrader-7 is an IKZF2 molecular glue degrader. IKZF2 degrader-7 binds to and alters the surface structure of the CRL4^CRBN E3 ubiquitin ligase, thereby recruiting and mediating the ubiquitination and proteasomal degradation of IKZF2. IKZF2 degrader-7 can be used for research on acute myeloid leukemia.

For research use only. We do not sell to patients.

Formula: C₂₅H₂₅N₅O₃
Molecular Weight:443.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IKZF2 degrader-7 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

IKZF2

Cereblon-DDB1

All IKZF Family Isoforms :

All Ligands for E3 Ligase Isoforms :

In Vitro

Anti-cancerOthers

Anti-cancer

IKZF2 degrader-7 (compound Z11) (1 μM; 16 h) degrades IKZF2 with a degradation rate of > 70% in Molm-13 cells^[1].

Others

IKZF2 degrader-7 (1 μM) inhibits CRBN/DDB1 binding with > 70% inhibition in the TR-FRET assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Molm-13 cells
Concentration:

1 μM
Incubation Time:

16 h
Result:

Effectively induced the degradation of IKZF2 protein in Molm-13 cells at a concentration of 1 μM, demonstrating excellent degradation activity with a degradation rate > 70% (Grade A).

Chemical Information

Molecular Weight 443.50
Formula C₂₅H₂₅N₅O₃
SMILES

N#CC1=CC=CC(CN2CCC(C3=CC(NN4C(CC5)C(NC5=O)=O)=C(C=C3)C4=O)CC2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xiaohua Chen, et al. Indolinone compounds, preparation method thereof, pharmaceutical composition and use thereof. WO2025056074A1. WIPO. 2025-03-20.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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IKZF2 degrader-7

All IKZF Family Isoforms

All Ligands for E3 Ligase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

IKZF2 degrader-7 Related Classifications

HY-190242 Related Classifications

Bioz

Keywords

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