IKZF3 degrader 2
IKZF3 degrader 2 is an IKZF3 Molecular glue degrader. IKZF3 degrader 2 alters the substrate specificity of CRBN to recruit the neo-substrate IKZF3 for ubiquitination and proteasomal degradation. IKZF3 degrader 2 can be used for research on multiple myeloma.
For research use only. We do not sell to patients.
- CAS No.: 2365401-02-9
- Formula: C13H12N2O3
- Molecular Weight:244.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IKZF3 |
CRBN |
In Vitro
IKZF3 degrader 2 (36 h) forms a typical MsCI4-bound 3-aminosuccinimide complex at 1.65 Å resolution (PDB 6R13), in which its amide linker forms a hydrogen bond with N50, and no clear protruding moiety interactions are observed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:OPM-2 human multiple myeloma cells
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Concentration:100 µM
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Incubation Time:24 h
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Result:Reduced IKZF3 levels.
Chemical Information
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CAS No. 2365401-02-9
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Molecular Weight 244.25
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Formula C13H12N2O3
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SMILES
O=C(NC(C1)C(NC1=O)=O)/C=C/C2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IKZF3 degrader 2 Related Classifications
HY-190193 Related Classifications
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