IL-4-IN-2
IL-4-IN-2 (Compound 14/analog 14) is a selective IL-4 inhibitor. IL-4-IN-2 binds to soluble IL-4 and inhibits IL-4-mediated signal transduction. IL-4-IN-2 suppresses STAT-6 phosphorylation induced by IL-13 and IL-4 in monocytes and B lymphocytes. IL-4-IN-2 is applicable to the research of allergic inflammation, cancer, autoimmune diseases, asthma and arthritis.
For research use only. We do not sell to patients.
- CAS No.: 3104023-24-4
- Formula: C18H14N4O2
- Molecular Weight:318.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IL-4 |
In Vitro
IL-4-IN-2 (2 μM) binds to soluble IL-4, resulting in a thermal stability change (ΔTm) of 1.66°C, while no thermal stability change meeting the binding criteria is observed for IL-2, IL-7, IL-13, and IL-21[1].
IL-4-IN-2 (50-5000 nM) dose-dependently inhibits IL-4-induced STAT-6 phosphorylation in THP-1 monocytes at concentrations of 50 nM, 500 nM, and 5 μM[1].
IL-4-IN-2 (50-5000 nM) inhibits IL-4-induced STAT-6 phosphorylation in Ramos B lymphocytes at concentrations of 50 nM, 500 nM, and 5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1
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Concentration:50 nM, 500 nM, 5 μM
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Incubation Time:30 min
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Result:Reduced IL-4-induced pSTAT6 immunofluorescence at 500 nM and produced almost no visible pSTAT6 signal at 5 μM.
Chemical Information
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CAS No. 3104023-24-4
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Molecular Weight 318.33
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Formula C18H14N4O2
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SMILES
N#CC1=C(N)N=C(C2=CC=C(N)C=C2)C=C1C3=CC(O)=C(O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IL-4-IN-2 Related Classifications
HY-187160 Related Classifications
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