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Cat. No.: HY-145572S

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Imlunestrant-d₄

Name: Imlunestrant-d4
Brand: MedChemExpress
SKU: HY-145572S
Price: 1000.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: LY-3484356-d₄)

Imlunestrant-d₄ (LY-3484356-d₄) is the deuterated-labeled Imlunestrant (HY-145572). Imlunestrant (LY-3484356) is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC).

For research use only. We do not sell to patients.

Formula: C₂₉H₂₀D₄F₄N₂O₃
Molecular Weight:528.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Imlunestrant-d₄ Chemical Structure

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Top Publications Citing

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
- Application
Chemical Information
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Biological Activity

Description

All Estrogen Receptor/ERR Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 2408840-26-4
Molecular Weight 528.53
Formula C₂₉H₂₀D₄F₄N₂O₃
SMILES

OC1=CC2=NC=C(C3=CC=C(C(F)(F)F)C=C3O[C@]4([H])C5=CC=C(C=C5)OC([2H])([2H])C([2H])([2H])N6CC(C6)CF)C4=C2C=C1
Synonyms

LY-3484356-d₄
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Komal L. Jhaveri, et al. A first-in-human phase 1a/b trial of LY3484356, an oral selective estrogen receptor (ER) degrader (SERD) in ER+ advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC): Results from the EMBER study. 2021 ASCO Annual Meeting I.

[2]. Cristina Hernando, et al. Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective. Int. J. Mol. Sci. 2021, 22(15), 7812.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References

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Imlunestrant-d4

All Estrogen Receptor/ERR Isoforms