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Cat. No.: HY-P1762A

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Influenza NP (147-155) TFA

Influenza NP (147-155) TFA is an MHC class I-restricted cytotoxic T lymphocyte (CTL) epitope derived from the nucleoprotein of influenza A virus. Influenza NP (147-155) TFA activates CTLs through peptide-MHC-I/TCR recognition, enabling CTLs to lyse target cells, and is efficiently recognized by K^d-restricted CTLs. Influenza NP (147-155) TFA prevents lethal heterosubtypic influenza A virus infection. Influenza NP (147-155) TFA can be used in influenza-related research.

For research use only. We do not sell to patients.

Formula: C₅₀H₈₃F₃N₁₆O₁₆
Molecular Weight:1221.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Influenza NP (147-155) TFA Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Adaptive ImmunityViral Infection

Adaptive Immunity

Viral Infection

Influenza NP (147-155) (TYQRTRALV) (100 fg-1 μg; 90 min) TFA is efficiently recognized by K^d-restricted HASI CTL on P815 cells, with a detection limit of 60 pg/mL (54 pM) and a lysis rate of 50% at approximately 10 pg/well^[2].
Influenza NP (147-155) TFA can be used to quantify naturally processed peptides in influenza-infected P1.HTR cells, at 220-540 copies per cell^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Viral InfectionAdaptive Immunity

Viral Infection

Adaptive Immunity

Influenza NP (147-155) (NPCTL) (10 µg; i.p.; primary immunization and booster immunization 2 weeks apart) TFA confers partial protection against lethal heterosubtypic H1N1 PR8 infection, in which CpG adjuvant alone is more favorable for survival than CpG + Alum adjuvant^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 1221.29
Formula C₅₀H₈₃F₃N₁₆O₁₆
Sequence

Thr-Tyr-Gln-Arg-Thr-Arg-Ala-Leu-Val
Sequence Shortening

TYQRTRALV
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. McGee MC, et al. Evolutionary conservation and positive selection of influenza A nucleoprotein CTL epitopes for universal vaccination. Journal of medical virology. 2022 Jun;94(6):2578-2587.

[2]. Falk K, et al. Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast. The Journal of experimental medicine. 1991 Aug 01;174(2):425-34.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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