Insecticidal agent 46
Insecticidal agent 46 is a voltage-gated sodium channel (VGSC) modulator. Insecticidal agent 46 shifts fast inactivation gating toward hyperpolarization and impairs the fast inactivation gate. Insecticidal agent 46 can be used as an insecticide.
For research use only. We do not sell to patients.
- CAS No.: 3119060-02-2
- Formula: C28H22BrF3N2
- Molecular Weight:523.39
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Insecticidal agent 46 (3 μM) shifts the fast inactivation V1/2 of DmNa22 expressed in Xenopus laevis oocytes by 13.23 mV in the hyperpolarizing direction without affecting activation gating[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HEK293T and Marc145 cells
-
Concentration:12.5, 25, 50, 100, 200 μM
-
Incubation Time:24 h (compound incubation); 4 h (CCK-8 incubation)
-
Result:Inhibited HEK293T and Marc145 cell proliferation with the following inhibition rates: at 200 μM, HEK293T 9.74%, Marc145 3.38%; at 100 μM, HEK293T 5.66%, Marc145 3.36%; at 50 μM, HEK293T 3.80%, Marc145 2.14%; at 25 μM, HEK293T 2.94%, Marc145 1.34%; at 12.5 μM, HEK293T 1.14%, Marc145 0.85%.
The IC50 values of LC-2 against both mammalian cell types exceeded 200 μM.
In Vivo
Insecticidal agent 46 (feeding) exhibits insecticidal activity against second-instar larvae of Drosophila melanogaster w1118, with an LC50 of 1.82 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3119060-02-2
-
Molecular Weight 523.39
-
Formula C28H22BrF3N2
-
SMILES
FC(C1=CC=CC=C1C[N+]2=C(C3=CC=CC=C3)N(CC4=CC=CC=C4)C5=CC=CC=C52)(F)F.[Br-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Insecticidal agent 46 Related Classifications
HY-189797 Related Classifications
Powered by Bioz
Keywords
- Insecticidal agent 46
- 3119060-02-2
- Insecticidal agent46
- Insecticidal agent-46
- Insecticide
- Sodium Channel
- Aedes aegypti
- Drosophila melanogaster
- Mythimna separata
- Periplaneta americana
- Plutella xylostella
- Rhopalosiphum padi
- fast inactivation gating
- hyperpolarization
- neurotoxic poisoning
- voltage-gated sodium channel
- Inhibitor
- inhibitor
- inhibit