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Cat. No.: HY-133700

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IRAK1 ligand-1

IRAK1 ligand-1 (core) is an IRAK1 ligand that can serve as a target protein ligand for the synthesis of PROTACs, such as JH-XIII-05-01 (HY-133616).

For research use only. We do not sell to patients.

CAS No.: 2374699-44-0
Formula: C₂₂H₂₂N₈O
Molecular Weight:414.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IRAK1 ligand-1 Chemical Structure

CAS No.: 2374699-44-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IRAK1 ligand-1 (core) is an IRAK1 ligand that can serve as a target protein ligand for the synthesis of PROTACs, such as JH-XIII-05-01 (HY-133616).

IC₅₀ & Target

^[1]

IRAK1

All IRAK Isoforms :

Chemical Information

CAS No. 2374699-44-0
Molecular Weight 414.46
Formula C₂₂H₂₂N₈O
SMILES

O=C(C1=NC(C2=NNC=C2)=CC=C1)NC3=CC(C4CCNCC4)=NN3C5=NC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hatcher JM, et al. Discovery of JH-XIII-05-01, a First-in-Class Dual IRAK1/IRAK4 Degrader for MYD88 Mutant Lymphomas. ACS medicinal chemistry letters. 2026 Sep 10;17(9):1977-1988.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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IRAK1 ligand-1

All IRAK Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

IRAK1 ligand-1 Related Classifications

HY-133700 Related Classifications

Bioz

Keywords

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