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Cat. No.: HY-N22057

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Isomeldenin

Isomeldenin is a natural product derived from the leaves of Azadirachta indica. Isomeldenin possesses antifungal activity and inhibits pustule formation in Puccinia arachidis. Isomeldenin exhibits antitumor activity, showing cytotoxic activity against SK-OV-3, MCF-7, and 3SKBr cells, and also decreases Bax and increases Bcl2 expression. Isomeldenin can be used in research related to fungal infections and has potential for research related to coronavirus infection.

For research use only. We do not sell to patients.

CAS No.: 186892-52-4
Formula: C₂₈H₃₈O₅
Molecular Weight:454.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

Isomeldenin Chemical Structure

CAS No.: 186892-52-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

Description

IC₅₀ & Target

^[2]

Bax

Bcl-2

All Bcl-2 Family Isoforms :

In Vitro

OthersAnti-cancerApoptosisFungal Infection

Others

Isomeldenin exhibits binding affinity for MERS-CoV spike glycoprotein, SARS-CoV-2 spike glycoprotein, SARS-CoV-2 main protease, and SARS-CoV-2 papain-like protease; moreover, it exhibits the strongest binding affinity for SARS-CoV-2 spike glycoprotein that binds to the human ACE2 receptor^[1].

Anti-cancer

Apoptosis

Isomeldenin (100 µg/mL; 24 h) exhibits cytotoxicity against SK-OV-3, MCF-7, and 3SKBr cell lines, with the highest mortality observed in SK-OV-3 cells^[2].
Isomeldenin decreases Bax and increases Bcl2 expression^[2].

Fungal Infection

Isomeldenin (compound 2) (0.005-5.0 μg/cm²; 48 h) reduces the formation of Puccinia arachidis rust pustules on detached Arachis hypogaea L. var. TMV-2 leaflets, achieving approximately 80% reduction at 0.005 μg/cm²^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

SK-OV-3, MCF-7, 3SKBr
Concentration:

100 µg/mL
Incubation Time:

24 h
Result:

Exhibited a death rate of 76.34% in SK-OV-3 cells.
Exhibited a death rate of 64.66% in MCF-7 cells.
Exhibited a death rate of 62.99% in 3SKBr cells.

Related Protocols :

Chemical Information

CAS No. 186892-52-4
Molecular Weight 454.60
Formula C₂₈H₃₈O₅
SMILES

C[C@]12[C@@](CC[C@@]3(C2=CC[C@H]3C4=COC=C4)C)([H])[C@@]5([C@@](C(C)(C(CC5)=O)C)([H])[C@H]([C@H]1OC(C)=O)O)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Trivedi A, et al. Prophylactic and therapeutic potential of selected immunomodulatory agents from Ayurveda against coronaviruses amidst the current formidable scenario: an analysis. Journal of biomolecular structure & dynamics. 2022;40(20):9648-9700.

[2]. Alaa Naseer Mohammed Ali, et al. Niosomes Containing Isomeldenin Plus Lupeol Induce Apoptosis of SK-OV-3, MCF-7, and 3SKBr Cell Lines and Alter the Expression of Apoptotic Genes. JCHR. 2024 Aug.

[3]. Suresh G, et al. Antifungal fractions and compounds from uncrushed Green Leaves of Azadirachta indica. Phytoparasitica. 1997;25:33-39.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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References

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Isomeldenin

All Bcl-2 Family Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Isomeldenin Related Classifications

HY-N22057 Related Classifications

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