Keto lovastatin
Keto lovastatin (Monacolin X) is an impurity of Lovastatin (HY-N0504) and also a competitive inhibitor of HMG-CoA reductase. Keto lovastatin exerts its cholesterol-lowering effect by blocking the rate-limiting step of endogenous cholesterol synthesis. Keto lovastatin can be used in research on hypercholesterolemia and atherosclerosis, and can also serve as an impurity reference standard in the research on the production and quality control of Lovastatin.
For research use only. We do not sell to patients.
- CAS No.: 96497-73-3
- Formula: C24H34O6
- Molecular Weight:418.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Keto lovastatin (up to 1000 ng/mL; 2 h) inhibits cholesterol synthesis in human hepatoma cells HEPG2, and its lactone and ring-opened acid forms exhibit comparable inhibitory activity, with no significant inhibitory effect on protein synthesis or fatty acid synthesis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 96497-73-3
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Molecular Weight 418.52
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Formula C24H34O6
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SMILES
O=C1OC(CC(C1)O)CCC2C(C)C=CC3=CC(CC(C32)OC(C(C)C(C)=O)=O)C
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Synonyms
Monacolin X
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keto lovastatin Related Classifications
HY-169818 Related Classifications
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