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Cat. No.: HY-N11627

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L-Indole-3-lactic acid

L-Indole-3-lactic acid is an L (-)-tryptophan metabolite found in strains of Bifidobacterium, Lactobacillus plantarum and Lactobacillus paraplantarum, and also an indole-based antioxidant. L-Indole-3-lactic acid is produced via the pathway that converts tryptophan into indole-3-pyruvic acid. L-Indole-3-lactic acid acts as a free radical scavenger to eliminate DPPH free radicals. L-Indole-3-lactic acid can be used in antioxidant and metabolism-related research.

For research use only. We do not sell to patients.

CAS No.: 7417-65-4
Formula: C₁₁H₁₁NO₃
Molecular Weight:205.21

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

L-Indole-3-lactic acid Chemical Structure

CAS No.: 7417-65-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

Protein/Amino Acid MetabolismOxidative StressOthers

Protein/Amino Acid Metabolism

L-Indole-3-lactic acid (0.05% L-tryptophan; 4 days) can be produced from L-tryptophan via 4-day incubation under anaerobic conditions using resting cells of 51 tested Bifidobacterium strains, with strain-dependent conversion rates^[1].
L-Indole-3-lactic acid is produced by B. breve B828 via the transformation of indole-3-pyruvic acid in both growing and resting cells, which validates the tryptophan metabolic cascade of tryptophan → indole-3-pyruvic acid → L-Indole-3-lactic acid^[1].

Oxidative Stress

L-Indole-3-lactic acid (20 min) exhibits DPPH free radical scavenging activity, with an EC₅₀ value of 13.4 mM^[2].

Others

L-Indole-3-lactic acid is produced at relatively high levels by Lactobacillus plantarum strains, with Lactobacillus paraplantarum strains producing similar levels, while other lactic acid bacteria species only produce low levels of this substance^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 7417-65-4
Appearance Solid
Molecular Weight 205.21
Formula C₁₁H₁₁NO₃
Color Off-white to light brown
SMILES

OC([C@@H](O)CC1=CNC2=CC=CC=C12)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source

Bifidobacterium spp
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Aragozzini F, et al. Indole-3-lactic acid as a tryptophan metabolite produced by Bifidobacterium spp. Appl Environ Microbiol. 1979 Sep;38(3):544-6. [Content Brief]

[2]. Suzuki Y, et al. Identification of antioxidants produced by Lactobacillus plantarum. Bioscience, biotechnology, and biochemistry. 2013;77(6):1299-302. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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