Larotaxel dihydrate
Larotaxel dihydrate (XRP9881 dihydrate) is an orally active and blood-brain barrier penetrant Microtubule stabilizer with an IC50 of 0.21 μM. Larotaxel dihydrate shows activity in Taxane-resistant tumor models. Larotaxel dihydrate exhibits antitumor activity in intracranial glioblastoma models. Larotaxel dihydrate can be used for research on advanced solid tumors.
For research use only. We do not sell to patients.
- CAS No.: 192573-38-9
- Formula: C45H57NO16
- Molecular Weight:867.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 192573-38-9
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Molecular Weight 867.93
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Formula C45H57NO16
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SMILES
O=C([C@]1([H])OC(C)=O)[C@@]23[C@@]([C@@H]([C@@]4(O)C(C)(C)C1=C([C@H](OC([C@H](O)[C@H](C5=CC=CC=C5)NC(OC(C)(C)C)=O)=O)C4)C)OC(C6=CC=CC=C6)=O)([H])[C@]7([C@@](OC7)([H])C[C@@H]2C3)OC(C)=O.O.O
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Synonyms
XRP9881 dihydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Larotaxel dihydrate Related Classifications
HY-125374A Related Classifications
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Keywords
- Larotaxel dihydrate
- 192573-38-9
- XRP9881 dihydrate
- Microtubule/Tubulin
- intracranial glioblastoma models
- P-glycoprotein-expressing multidrug-resistant cancer cells
- taxane-resistant tumor models
- cell cycle arrest
- blood-brain barrier penetration
- microtubule-stabilizing taxane
- cold-induced depolymerization
- mitotic spindle function
- microtubules
- oral activity
- Inhibitor
- inhibitor
- inhibit